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Tclin
NDUFA1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371437
  • ENSP00000360492
  • ENSG00000125356

Symbol
  • MWFE
  • ZNF183
  • CI-MWFE
  • MC1DN12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
virus perturbation
0.96
kinase perturbation
0.95
co-expressed gene
0.94
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A1
VGNC:7461
100608263
Macaque
NADH:ubiquinone oxidoreductase subunit A1
694635
Mouse
MGI:1929511
54405
Rat
RGD:1560955
363441
Horse
NADH:ubiquinone oxidoreductase subunit A1
VGNC:20620
100058835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A1
Macaque
NADH:ubiquinone oxidoreductase subunit A1
Mouse
Rat
Horse
NADH:ubiquinone oxidoreductase subunit A1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15239-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (154)
1 – 10 of 154
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.986927766
p_ni: 0.000087725
p_wrong: 0.012984509
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.919835989
p_ni: 0.000323056
p_wrong: 0.079840955
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.893633082
p_ni: 0.000815165
p_wrong: 0.105551753
Score: 0.998
Data Source: BioPlex,STRINGDB
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.868650561
p_ni: 0.055398022
p_wrong: 0.075951417
Score: 0.171
Data Source: BioPlex,STRINGDB
NDUFA6
Tclin
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
Score: 0.999
Data Source: STRINGDB
NDUFA2
Tclin
Family: Enzyme
Novelty: 0.02698508
Score: 0.999
Data Source: STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
Score: 0.999
Data Source: STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
Score: 0.999
Data Source: STRINGDB
NDUFC1
Tclin
Family: Enzyme
Novelty: 0.48303612
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  119.74

PubMed score by year
PubTator Score  23.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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