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Tbio
MRPS12
28S ribosomal protein S12, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308018
  • ENSP00000308845
  • ENSG00000128626
  • ENST00000402029
  • ENSP00000384579
  • ENST00000407800
  • ENSP00000384952
  • ENST00000634246
  • ENSP00000488926
  • ENSG00000283018
  • ENST00000634400
  • ENSP00000489467
  • ENST00000634704
  • ENSP00000489374

Symbol
  • RPMS12
  • RPSM12
  • RPS12
  • RPMS12
  • RPSM12
  • MPR-S12
  • MT-RPS12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
kinase perturbation
0.88
transcription factor perturbation
0.8
interacting protein
0.79
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
1
1
81.1
SIR2-like protein 2 measurement
1
1
1
81.1
serum gamma-glutamyl transferase measurement
1
1
1
50.6
serum gamma-glutamyl transferase measurement
1
1
1
50.6
diastolic blood pressure
1
1
1
40.7
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
SIR2-like protein 2 measurement
1
81.1
SIR2-like protein 2 measurement
1
81.1
serum gamma-glutamyl transferase measurement
1
50.6
serum gamma-glutamyl transferase measurement
1
50.6
diastolic blood pressure
1
40.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S12
VGNC:2310
468873
Mouse
MGI:1346333
24030
Rat
RGD:1306221
292758
Dog
mitochondrial ribosomal protein S12
VGNC:43410
484517
Horse
mitochondrial ribosomal protein S12
VGNC:20353
100064399
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S12
Mouse
Rat
Dog
mitochondrial ribosomal protein S12
Horse
mitochondrial ribosomal protein S12
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15235-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (392)
1 – 10 of 392
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.984141451
p_ni:  0.014905983
p_wrong:  0.000952566
Score:  0.181
Data Source:  BioPlex,STRINGDB
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.941954905
p_ni:  0.058045095
Data Source:  BioPlex
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.897976265
p_ni:  0.102023059
p_wrong:  6.76e-7
Score:  0.976
Data Source:  BioPlex,STRINGDB
GLRX
Tbio
Novelty:  0.00111903
p_int:  0.86261421
p_ni:  0.109878658
p_wrong:  0.027507131
Data Source:  BioPlex
METAP1
Tchem
Family:  Enzyme
Novelty:  0.01816253
p_int:  0.842439283
p_ni:  0.157560071
p_wrong:  6.47e-7
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.835255075
p_ni:  0.164744925
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.798043928
p_ni:  0.201956071
p_wrong:  1e-9
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.785691228
p_ni:  0.214308765
p_wrong:  8e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
MRPS16
Tbio
Novelty:  0.24108603
Score:  0.999
Data Source:  STRINGDB
MRPL17
Tdark
Novelty:  1.20541719
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.33

PubMed score by year
PubTator Score  9.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer