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Tbio
LAMA5
Laminin subunit alpha-5

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), lam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252999
  • ENSP00000252999
  • ENSG00000130702

Symbol
  • KIAA0533
  • KIAA1907
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.9
transcription factor perturbation
0.88
disease perturbation
0.87
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.9   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.9   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
98.6
1
1
0
1.1
81.3
glomerular filtration rate
1
1
1
32.9
platelet crit
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.6
0
1.1
81.3
glomerular filtration rate
1
32.9
platelet crit
1
25.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:105382
16776
Rat
RGD:621023
140433
Horse
laminin subunit alpha 5
VGNC:19564
100058057
Cow
laminin subunit alpha 5
VGNC:30771
506751
Chicken
laminin subunit alpha 5
CGNC:3962
428148
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
laminin subunit alpha 5
Cow
laminin subunit alpha 5
Chicken
laminin subunit alpha 5
Protein Structure (1 Structure, 13 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Degradation of the extracellular matrix
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Degradation of the extracellular matrix
ECM proteoglycans
Extracellular matrix organization
Immune System
Gene Ontology Terms (40)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (127)
1 – 10 of 127
CRP
Tbio
Novelty: 0.00001517
p_int: 0.999999179
p_ni: 8.21e-7
Score: 0.157
Data Source: BioPlex,STRINGDB
OS9
Tbio
Novelty: 0.01490339
p_int: 0.998849301
p_ni: 0.0011507
Data Source: BioPlex
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.996033158
p_ni: 0.003966842
Data Source: BioPlex
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.99501137
p_ni: 0.00498863
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.994966921
p_ni: 0.005033061
p_wrong: 1.8e-8
Data Source: BioPlex
BCAM
Tbio
Novelty: 0.01697541
p_int: 0.993022444
p_ni: 0.0069775
p_wrong: 5.6e-8
Score: 0.727
Data Source: BioPlex,STRINGDB
LRRTM4
Tbio
Novelty: 0.07741851
p_int: 0.986951088
p_ni: 0.013048907
p_wrong: 5e-9
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.985175369
p_ni: 0.014824619
p_wrong: 1.2e-8
Data Source: BioPlex
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.981846912
p_ni: 0.018152883
p_wrong: 2.06e-7
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.96324444
p_ni: 0.036755532
p_wrong: 2.7e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  52.90

PubMed score by year
PubTator Score  32.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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