You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KMO
Kynurenine 3-monooxygenase

Protein Summary
Description
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366557
  • ENSP00000355515
  • ENSG00000117009
  • ENST00000366558
  • ENSP00000355516
  • ENST00000366559
  • ENSP00000355517

Symbol
  • dJ317G22.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.75
gene perturbation
0.75
cellular component
0.73
molecular function
0.73
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.61   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.61   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 136
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (136)
1 – 10 of 136
Protein-Protein Interactions (123)
1 – 10 of 123
HSPA7
Tdark
p_int:  0.999996676
p_wrong:  0.000003323
Data Source:  BioPlex
GPHN
Tbio
Novelty:  0.0020752
p_int:  0.945680889
p_ni:  0.054319111
Score:  0.454
Data Source:  BioPlex,STRINGDB
KYNU
Tchem
Family:  Enzyme
Novelty:  0.01372383
Score:  0.999
Data Source:  STRINGDB
AADAT
Tchem
Family:  Enzyme
Novelty:  0.00678753
Score:  0.987
Data Source:  STRINGDB
AFMID
Tbio
Family:  Enzyme
Novelty:  0.02027656
Score:  0.985
Data Source:  STRINGDB
HAAO
Tbio
Family:  Enzyme
Novelty:  0.02869073
Score:  0.985
Data Source:  STRINGDB
KYAT1
Tbio
Family:  Enzyme
Novelty:  0.01232903
Score:  0.984
Data Source:  STRINGDB
KYAT3
Tbio
Family:  Enzyme
Novelty:  0.05845124
Score:  0.982
Data Source:  STRINGDB
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
Score:  0.949
Data Source:  STRINGDB
ACMSD
Tchem
Family:  Enzyme
Novelty:  0.02825532
Score:  0.915
Data Source:  STRINGDB
Pathways (18)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kynurenine 3-monooxygenase
VGNC:11491
469730
Macaque
kynurenine 3-monooxygenase
707314
Mouse
MGI:2138151
98256
Rat
RGD:620610
59113
Dog
kynurenine 3-monooxygenase
VGNC:42488
480093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kynurenine 3-monooxygenase
Macaque
kynurenine 3-monooxygenase
Mouse
Rat
Dog
kynurenine 3-monooxygenase
Publication Statistics
PubMed Score 88.61
PubMed score by year
PubTator Score 101.69
PubTator score by year