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Tchem
GNPAT
Dihydroxyacetone phosphate acyltransferase

Protein Summary
Description
This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366647
  • ENSP00000355607
  • ENSG00000116906

Symbol
  • DAPAT
  • DHAPAT
  • DAPAT
  • RCDP2
  • DAP-AT
  • DHAPAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
co-expressed gene
0.87
histone modification site profile
0.84
interacting protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.48   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.48   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
83.1
hemoglobin measurement
2
2
2
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
83.1
hemoglobin measurement
2
80.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glyceronephosphate O-acyltransferase
VGNC:6834
741681
Macaque
glyceronephosphate O-acyltransferase
713603
Mouse
MGI:1343460
14712
Rat
RGD:620179
84470
Dog
glyceronephosphate O-acyltransferase
VGNC:41330
479204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glyceronephosphate O-acyltransferase
Macaque
glyceronephosphate O-acyltransferase
Mouse
Rat
Dog
glyceronephosphate O-acyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15228-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal protein import
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Peroxisomal protein import
Phospholipid metabolism
Protein-Protein Interactions (177)
1 – 10 of 177
BSG
Tbio
Novelty:  0.0010285
p_int:  0.999988042
p_ni:  0.000011958
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999884358
p_ni:  0.000115642
Data Source:  BioPlex
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.999793257
p_ni:  0.000206734
p_wrong:  1e-8
Data Source:  BioPlex
TTC25
Tdark
Novelty:  0.23064129
p_int:  0.999689524
p_ni:  0.000310476
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.999671994
p_ni:  0.000328006
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999548841
p_ni:  0.000451159
Data Source:  BioPlex
S100A9
Tchem
Novelty:  0.00185141
p_int:  0.99950791
p_ni:  0.00049209
Data Source:  BioPlex
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.999387778
p_ni:  0.000612222
Data Source:  BioPlex
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.999333291
p_ni:  0.000666709
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.998962595
p_ni:  0.001037378
p_wrong:  2.7e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  87.48

PubMed score by year
PubTator Score  66.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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