Tbio NKRF NF-kappa-B-repressing factor

Protein Summary

Description

Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• O15226
• G3V1N1
• Q4VC41
• Q9UJ91
• NFkB-repressing factor

Gene Name

• NKRF

Ensembl ID

• ENST00000304449
• ENSP00000304803
• ENSG00000186416
• ENST00000371527
• ENSP00000360582
• ENST00000542113
• ENSP00000442308

Symbol

• ITBA4
• NRF
• NRF
• ITBA4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
interacting protein	0.82
co-expressed gene	0.79
tissue sample	0.74
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Nf-kappa-b-repressing Factor

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Nf-kappa-b-repressing Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.91   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.91   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0