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Tbio
GPR182
G-protein coupled receptor 182

Protein Summary
Description
Orphan receptor. Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300098
  • ENSP00000300098
  • ENSG00000166856

Symbol
  • ADMR
  • AMR
  • 7TMR
  • ADMR
  • AM-R
  • G10D
  • L1-R
  • gamrh
  • hrhAMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.59
tissue
0.54
cell line
0.52
cell type or tissue
0.52
pathway
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.25   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.25   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
ADM
Tbio
Novelty:  0.0004958
Score:  0.8
Data Source:  STRINGDB
SAG
Tbio
Novelty:  0.00040944
Score:  0.668
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.559
Data Source:  STRINGDB
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.557
Data Source:  STRINGDB
TTC32
Tdark
Novelty:  0.90327428
Score:  0.557
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.556
Data Source:  STRINGDB
ARRDC5
Tdark
Novelty:  0.22231503
Score:  0.51
Data Source:  STRINGDB
RAMP2
Tclin
Novelty:  0.01086538
Score:  0.494
Data Source:  STRINGDB
USP33
Tbio
Family:  Enzyme
Novelty:  0.04411285
Score:  0.491
Data Source:  STRINGDB
DUSP5
Tchem
Family:  Enzyme
Novelty:  0.00197547
Score:  0.481
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
84.2
2
1
0
1.1
75
adult onset asthma
1
1
0
1.1
72.3
eosinophil count
1
1
1
69.5
eosinophil percentage of leukocytes
1
1
1
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
84.2
0
1.1
75
adult onset asthma
0
1.1
72.3
eosinophil count
1
69.5
eosinophil percentage of leukocytes
1
69.4
Find similar targets by:
IDG Resources
Genetic Construct
GPR182-Tango
image for GPR182-Tango
Details:
  • Vector:  addgene66341
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR182-Tango
Order Genetic Construct from:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 182
VGNC:13095
100610034
Macaque
G protein-coupled receptor 182
713866
Mouse
MGI:109545
11536
Rat
RGD:61903
29307
Dog
G protein-coupled receptor 182
VGNC:41422
481120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 182
Macaque
G protein-coupled receptor 182
Mouse
Rat
Dog
G protein-coupled receptor 182
Publication Statistics
PubMed Score 88.25
PubMed score by year
PubTator Score 57.88
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title