Tbio GPR182 G-protein coupled receptor 182

Protein Summary

Description

Orphan receptor. Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15218

Gene Name

• GPR182

Ensembl ID

• ENST00000300098
• ENSP00000300098
• ENSG00000166856

Symbol

• ADMR
• AMR
• 7TMR
• ADMR
• AM-R
• G10D
• L1-R
• gamrh
• hrhAMR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.59
tissue	0.54
cell line	0.52
cell type or tissue	0.52
pathway	0.45

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 182

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adrenomedullin Receptor / G-protein Coupled Receptor 182

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.21   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.21   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0