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Tbio
GSTA4
Glutathione S-transferase A4

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370959
  • ENSP00000359998
  • ENSG00000170899
  • ENST00000370960
  • ENSP00000359999
  • ENST00000370963
  • ENSP00000360002

Symbol
  • GTA4
  • GSTA4-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
PubMedID
0.93
transcription factor binding site profile
0.9
chemical
0.85
disease
0.84


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.51   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.51   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase alpha 4
VGNC:2851
462771
Macaque
glutathione S-transferase alpha 4
709666
Dog
glutathione S-transferase alpha 4
474939
Horse
glutathione S-transferase A4
100056597
Cow
glutathione S-transferase alpha 4
VGNC:53979
533917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase alpha 4
Macaque
glutathione S-transferase alpha 4
Dog
glutathione S-transferase alpha 4
Horse
glutathione S-transferase A4
Cow
glutathione S-transferase alpha 4
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15217-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (95)
1 – 10 of 95
GSTA2
Tbio
Family: Enzyme
Novelty: 0.01131783
p_int: 0.999999933
p_ni: 6.5e-8
p_wrong: 2e-9
Score: 0.886
Data Source: BioPlex,STRINGDB
GSTA1
Tchem
Family: Enzyme
Novelty: 0.00308319
p_int: 0.99999953
p_ni: 1.07e-7
p_wrong: 3.63e-7
Score: 0.837
Data Source: BioPlex,STRINGDB
TRIB2
Tbio
Family: Kinase
Novelty: 0.02240668
p_int: 0.999996485
p_ni: 0.00000339
p_wrong: 1.25e-7
Score: 0.23
Data Source: BioPlex,STRINGDB
GSTO1
Tchem
Family: Enzyme
Novelty: 0.00800915
Score: 0.919
Data Source: STRINGDB
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
Score: 0.904
Data Source: STRINGDB
GPX2
Tbio
Family: Enzyme
Novelty: 0.00479104
Score: 0.892
Data Source: STRINGDB
GPX7
Tbio
Family: Enzyme
Novelty: 0.01342855
Score: 0.892
Data Source: STRINGDB
GSTT2B
Tbio
Family: Enzyme
Novelty: 0.02334158
Score: 0.885
Data Source: STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
Score: 0.88
Data Source: STRINGDB
GSTM1
Tbio
Family: Enzyme
Novelty: 0.00023264
Score: 0.88
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.51

PubMed score by year
PubTator Score  59.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer