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Tbio
WDR46
WD repeat-containing protein 46

Protein Summary
Description
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374617
  • ENSP00000363746
  • ENSG00000227057
  • ENST00000383208
  • ENSP00000372695
  • ENSG00000206284
  • ENST00000432609
  • ENSP00000402869
  • ENSG00000236222
  • ENST00000432933
  • ENSP00000399454
  • ENSG00000204221
  • ENST00000457382
  • ENSP00000405614
  • ENSG00000226916

Symbol
  • BING4
  • C6orf11
  • UTP7
  • BING4
  • FP221
  • C6orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
cell line
0.61
transcription factor perturbation
0.61
cellular component
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (374)
RRP7A
Tbio
Novelty:  0.11315285
p_int:  0.999981134
p_ni:  0.000018866
Score:  0.998
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999967528
p_ni:  0.000032472
Score:  0.274
Data Source:  BioPlex,STRINGDB
NOL6
Tbio
Novelty:  0.10002413
p_int:  0.999947579
p_ni:  0.00005242
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRIM71
Tbio
Family:  Enzyme
Novelty:  0.01164618
p_int:  0.999587535
p_ni:  0.000412465
p_wrong:  1e-9
Data Source:  BioPlex
ZNF317
Tdark
Family:  TF
Novelty:  1.58030176
p_int:  0.999367044
p_ni:  0.000632375
p_wrong:  5.81e-7
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.998157083
p_ni:  0.000347414
p_wrong:  0.001495503
Data Source:  BioPlex
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.998026285
p_ni:  0.001973362
p_wrong:  3.53e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZFP37
Tbio
Family:  TF
Novelty:  0.12072115
p_int:  0.995999898
p_ni:  0.000003146
p_wrong:  0.003996956
Score:  0.189
Data Source:  BioPlex,STRINGDB
NSD2
Tchem
Family:  TF; Epigenetic
Novelty:  0.00594188
p_int:  0.993998655
p_ni:  0.006001345
Score:  0.167
Data Source:  BioPlex,STRINGDB
FTSJ3
Tbio
Family:  Enzyme
Novelty:  0.01888973
p_int:  0.989680838
p_ni:  0.010319162
Score:  0.991
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (55)
Items per page:
1 – 5 of 55
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
Items per page:
1 – 5 of 55
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 46
718220
Mouse
MGI:1931871
57315
Rat
RGD:2209
309628
Dog
WD repeat domain 46
VGNC:48369
481738
Horse
WD repeat domain 46
VGNC:25000
100052757
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 46
Mouse
Rat
Dog
WD repeat domain 46
Horse
WD repeat domain 46
Publication Statistics
PubMed Score 6.68
PubMed score by year
PubTator Score 3.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title