Tbio WDR46 WD repeat-containing protein 46

Protein Summary

Description

Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Uniprot Accession IDs

• O15213
• A6NDP5
• Q5HYZ0
• Q5STK5
• Q5STR3

Gene Name

• WDR46

Ensembl ID

• ENST00000374617
• ENSP00000363746
• ENSG00000227057
• ENST00000383208
• ENSP00000372695
• ENSG00000206284
• ENST00000432609
• ENSP00000402869
• ENSG00000236222
• ENST00000432933
• ENSP00000399454
• ENSG00000204221
• ENST00000457382
• ENSP00000405614
• ENSG00000226916

Symbol

• BING4
• C6orf11
• UTP7
• BING4
• FP221
• C6orf11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.85
cell line	0.61
transcription factor perturbation	0.61
cellular component	0.6
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.87   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0