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Tbio
PFDN6
Prefoldin subunit 6

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374606
  • ENSP00000363734
  • ENSG00000204220
  • ENST00000374607
  • ENSP00000363735
  • ENST00000374610
  • ENSP00000363738
  • ENST00000383207
  • ENSP00000372694
  • ENSG00000206283
  • ENST00000395131
  • ENSP00000378563
  • ENST00000399383
  • ENSP00000382314
  • ENST00000399385
  • ENSP00000382316
  • ENST00000412289
  • ENSP00000402212
  • ENSG00000224782
  • ENST00000425878
  • ENSP00000395462
  • ENST00000431830
  • ENSP00000402553
  • ENSG00000235692
  • ENST00000432391
  • ENSP00000400152
  • ENST00000442285
  • ENSP00000404773
  • ENST00000445559
  • ENSP00000398171
  • ENSG00000237335
  • ENST00000448594
  • ENSP00000403771
  • ENST00000451970
  • ENSP00000415678
  • ENST00000452658
  • ENSP00000412319
  • ENST00000547641
  • ENSP00000449925
  • ENST00000547952
  • ENSP00000448784
  • ENST00000548040
  • ENSP00000447540
  • ENST00000552711
  • ENSP00000448607

Symbol
  • HKE2
  • PFD6
  • HKE2
  • KE-2
  • PFD6
  • H2-KE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
transcription factor perturbation
0.61
tissue sample
0.6
interacting protein
0.52
cell line
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (178)
1 – 10 of 178
PFDN4
Tbio
Novelty: 0.02826158
p_int: 0.999605185
p_ni: 0.000394815
Score: 0.999
Data Source: BioPlex,STRINGDB
VBP1
Tbio
Novelty: 0.05609599
p_int: 0.963654549
p_ni: 0.036345451
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.960127761
p_ni: 0.039872239
Score: 0.569
Data Source: BioPlex,STRINGDB
DCAF5
Tdark
Novelty: 1.07807487
p_int: 0.952890688
p_ni: 0.047109312
Score: 0.699
Data Source: BioPlex,STRINGDB
UXT
Tbio
Novelty: 0.0402855
p_int: 0.866106659
p_ni: 0.133893341
Score: 0.881
Data Source: BioPlex,STRINGDB
PFDN5
Tbio
Novelty: 0.09272547
Score: 0.999
Data Source: STRINGDB
PFDN1
Tbio
Novelty: 0.1113025
Score: 0.999
Data Source: STRINGDB
PFDN2
Tbio
Novelty: 0.12469692
Score: 0.999
Data Source: STRINGDB
CCT8
Tbio
Novelty: 0.03009096
Score: 0.968
Data Source: STRINGDB
CCT4
Tbio
Novelty: 0.01624952
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.68

PubMed score by year
PubTator Score  15.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer