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Tbio
RGL2
Ral guanine nucleotide dissociation stimulator-like 2

Protein Summary
Description
Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383204
  • ENSP00000372691
  • ENSG00000206282
  • ENST00000413136
  • ENSP00000407088
  • ENSG00000224841
  • ENST00000416548
  • ENSP00000412152
  • ENSG00000228736
  • ENST00000452084
  • ENSP00000390098
  • ENSG00000237825
  • ENST00000497454
  • ENSP00000420211
  • ENSG00000237441

Symbol
  • RAB2L
  • KE1.5
  • RAB2L
  • HKE1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.85
transcription factor binding site profile
0.77
histone modification site profile
0.69
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.24   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.962
Data Source:  STRINGDB
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
Score:  0.945
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.942
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.894
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.887
Data Source:  STRINGDB
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
Score:  0.887
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.883
Data Source:  STRINGDB
MRAS
Tbio
Family:  Enzyme
Novelty:  0.01544981
Score:  0.876
Data Source:  STRINGDB
PFDN6
Tbio
Novelty:  0.01632101
Score:  0.816
Data Source:  STRINGDB
KIFC1
Tchem
Novelty:  0.00982095
Score:  0.807
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ral guanine nucleotide dissociation stimulator like 2
718198
Mouse
MGI:107483
19732
Rat
RGD:1302985
294283
Dog
ral guanine nucleotide dissociation stimulator like 2
VGNC:45513
481739
Cow
ral guanine nucleotide dissociation stimulator like 2
VGNC:33904
504334
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ral guanine nucleotide dissociation stimulator like 2
Mouse
Rat
Dog
ral guanine nucleotide dissociation stimulator like 2
Cow
ral guanine nucleotide dissociation stimulator like 2
Publication Statistics
PubMed Score 21.24
PubMed score by year
PubTator Score 11.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title