Protein Summary
May play an important role in the control of the immune response and during pregnancy. This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
- ENST00000256412
- ENSP00000256412
- ENSG00000134028
- ENST00000522298
- ENSP00000428993
- M12.219
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
kinase perturbation | 0.76 | ||
protein domain | 0.58 | ||
microRNA | 0.57 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.45 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 151 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.45 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 151 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0