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Tbio
SMAD9
Mothers against decapentaplegic homolog 9

Protein Summary
Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350148
  • ENSP00000239885
  • ENSG00000120693
  • ENST00000379826
  • ENSP00000369154
  • ENST00000399275
  • ENSP00000382216

Symbol
  • MADH6
  • MADH9
  • SMAD8
  • PPH2
  • MADH6
  • MADH9
  • SMAD8
  • SMAD8A
  • SMAD8B
  • SMAD8/9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.8
virus perturbation
0.79
tissue sample
0.68
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.66   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.66   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
p_int:  0.999999982
p_wrong:  1.8e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.99999992
p_ni:  1e-9
p_wrong:  8e-8
Score:  0.749
Data Source:  BioPlex,STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.999266515
p_ni:  0.000733485
Score:  0.707
Data Source:  BioPlex,STRINGDB
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.945356199
p_ni:  0.053937727
p_wrong:  0.000706074
Score:  0.199
Data Source:  BioPlex,STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.944553982
p_ni:  0.055411974
p_wrong:  0.000034044
Score:  0.183
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.895342294
p_ni:  0.104657686
p_wrong:  2.1e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
Score:  0.991
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.987
Data Source:  Reactome,STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.985
Data Source:  Reactome,STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
Score:  0.984
Data Source:  Reactome,STRINGDB
Pathways (55)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
81.5
1
1
0
1.1
46.9
bone density
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
81.5
0
1.1
46.9
bone density
1
24.5
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 9
VGNC:5111
452539
Macaque
SMAD family member 9
694572
Mouse
MGI:1859993
55994
Dog
SMAD family member 9
VGNC:46525
486006
Horse
SMAD family member 9
VGNC:23315
100062493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMAD family member 9
Macaque
SMAD family member 9
Mouse
Dog
SMAD family member 9
Horse
SMAD family member 9
Publication Statistics
PubMed Score 167.66
PubMed score by year
PubTator Score 57.71
PubTator score by year