Protein Summary
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000392957
- ENSP00000376684
- ENSG00000106123
- ENST00000442129
- ENSP00000410789
- HEP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
small molecule | 1 | ||
molecular function | 0.98 | ||
gene perturbation | 0.95 | ||
histone modification site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 56.02 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 56.02 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (9)
Protein-Protein Interactions (103)
FKBP5
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999724573
p_ni: 0.000275427
Score: 0.259
Data Source: BioPlex,STRINGDB
RABAC1
Novelty: 0.01749453
p_int: 0.924865061
p_ni: 0.001880978
p_wrong: 0.073253961
Data Source: BioPlex
CADM4
Novelty: 0.05034541
p_int: 0.823694965
p_ni: 0.004567262
p_wrong: 0.171737773
Data Source: BioPlex
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (25)
Reactome (5)
KEGG (1)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (7)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 27 | 0 | 1.7 | 97.8 | |||||
reticulocyte measurement | 2 | 2 | 3 | 80.6 | |||||
reticulocyte count | 4 | 2 | 4 | 79.4 | |||||
lymphocyte count | 1 | 1 | 1 | 49.5 | |||||
HbA1c measurement | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.7 | 97.8 | |||||
reticulocyte measurement | 3 | 80.6 | |||||
reticulocyte count | 4 | 79.4 | |||||
lymphocyte count | 1 | 49.5 | |||||
HbA1c measurement | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor B6 | VGNC:14007 | 463799 | |||||
Macaque | EPH receptor B6 | 704886 | ||||||
Mouse | MGI:1096338 | 13848 | ||||||
Rat | RGD:1306163 | 312275 | ||||||
Dog | EPH receptor B6 | VGNC:40414 | 475519 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | EPH receptor B6 | |||||
Macaque | EPH receptor B6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor B6 | |||||
Publication Statistics
PubMed Score 56.02
PubMed score by year
PubTator Score 44.98
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (62)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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