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Tchem
EPHB6
Ephrin type-B receptor 6

Protein Summary
Description
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392957
  • ENSP00000376684
  • ENSG00000106123
  • ENST00000442129
  • ENSP00000410789

Symbol
  • HEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
small molecule
1
molecular function
0.98
gene perturbation
0.95
histone modification site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.02   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.02   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (103)
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999724573
p_ni:  0.000275427
Score:  0.259
Data Source:  BioPlex,STRINGDB
RABAC1
Tbio
Novelty:  0.01749453
p_int:  0.924865061
p_ni:  0.001880978
p_wrong:  0.073253961
Data Source:  BioPlex
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.823694965
p_ni:  0.004567262
p_wrong:  0.171737773
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
Score:  0.995
Data Source:  STRINGDB
EFNB1
Tbio
Novelty:  0.00523161
Score:  0.993
Data Source:  STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
Score:  0.993
Data Source:  STRINGDB
EFNA4
Tbio
Novelty:  0.03628159
Score:  0.992
Data Source:  STRINGDB
EFNA1
Tbio
Family:  Kinase
Novelty:  0.00732252
Score:  0.992
Data Source:  STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
Score:  0.992
Data Source:  STRINGDB
EFNA3
Tbio
Novelty:  0.01819539
Score:  0.992
Data Source:  STRINGDB
Pathways (25)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
27
0
1.7
97.8
reticulocyte measurement
2
2
3
80.6
reticulocyte count
4
2
4
79.4
lymphocyte count
1
1
1
49.5
HbA1c measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
97.8
reticulocyte measurement
3
80.6
reticulocyte count
4
79.4
lymphocyte count
1
49.5
HbA1c measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B6
VGNC:14007
463799
Macaque
EPH receptor B6
704886
Mouse
MGI:1096338
13848
Rat
RGD:1306163
312275
Dog
EPH receptor B6
VGNC:40414
475519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor B6
Macaque
EPH receptor B6
Mouse
Rat
Dog
EPH receptor B6
Publication Statistics
PubMed Score 56.02
PubMed score by year
PubTator Score 44.98
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title