Tchem EPHB6 Ephrin type-B receptor 6

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Eph Family / Ephrin Type-b Receptor 6

Protein Summary

Description

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O15197
• A4D2I7
• A8CDT5
• D3DXD3
• Q2TB23
• Q2TB24

Gene Name

• EPHB6

Ensembl ID

• ENST00000392957
• ENSP00000376684
• ENSG00000106123
• ENST00000442129
• ENSP00000410789

Symbol

• HEP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
small molecule	1
molecular function	0.98
gene perturbation	0.95
histone modification site profile	0.77

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.52   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.52   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

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1 – 2 of 2

dasatinib

EPHB6Tchem Kinase

Kd: 10.41

crizotinib

EPHB6Tchem Kinase

Kd: 8.22

Active Ligands (5)

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1 – 5 of 5

CHEMBL1230609

EPHB6Tchem Kinase

Kd: 8.89

CHEMBL572878

EPHB6Tchem Kinase

Kd: 7.55

CHEMBL386051

EPHB6Tchem Kinase

Kd: 8.7

CHEMBL1908396

EPHB6Tchem Kinase

Kd: 8.3

compound 20 [PMID: 23489211]

EPHB6Tchem Kinase

IC50: 5.23999977

Pathways (25)

Reactome (5)

KEGG (1)

WikiPathways (19)

Axon guidance (R-HSA-422475)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Reactome	Ephrin signaling	19 targets	R-HSA-3928664

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Ephrin signaling	19 targets	R-HSA-3928664

Gene Ontology Terms (19)

Functions (7)

Components (7)

Processes (5)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
protein tyrosine kinase activity	Inferred from Experiment (EXP)	Reactome
transmembrane receptor protein tyrosine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transmembrane signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transmembrane-ephrin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ephrin receptor activity	Traceable Author Statement (TAS)	ProtInc
signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (103)

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1 – 10 of 103

• See Interactions on String-DB

FKBP5

Tchem

Family: Enzyme

Novelty: 0.00214511

p_int: 0.999724573

p_ni: 0.000275427

Score: 0.259

Data Source: BioPlex,STRINGDB

RABAC1

Tbio

Novelty: 0.01749453

p_int: 0.924865061

p_ni: 0.001880978

p_wrong: 0.073253961

Data Source: BioPlex

CADM4

Tbio

Novelty: 0.05034541

p_int: 0.823694965

p_ni: 0.004567262

p_wrong: 0.171737773

Data Source: BioPlex

EFNB2

Tbio

Novelty: 0.00255095

Score: 0.995

Data Source: STRINGDB

EFNB1

Tbio

Novelty: 0.00523161

Score: 0.993

Data Source: STRINGDB

EFNB3

Tbio

Novelty: 0.0120367

Score: 0.993

Data Source: STRINGDB

EFNA4

Tbio

Novelty: 0.03628159

Score: 0.992

Data Source: STRINGDB

EFNA1

Tbio

Family: Kinase

Novelty: 0.00732252

Score: 0.992

Data Source: STRINGDB

EFNA5

Tbio

Novelty: 0.00134985

Score: 0.992

Data Source: STRINGDB

EFNA3

Tbio

Novelty: 0.01819539

Score: 0.992

Data Source: STRINGDB

Publication Statistics

PubMed Score  53.52

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PubTator Score  44.98

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

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PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

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Structural Annotations

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UniProt Keyword Find Similar Targets

Alternative splicing
ATP-binding
Complete proteome
Direct protein sequencing
Glycoprotein
Membrane
Nucleotide-binding
Polymorphism
Receptor
Reference proteome

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
immune system phenotype
reproductive system phenotype