Tbio PGRMC2 Membrane-associated progesterone receptor component 2

Protein Summary

Description

Receptor for steroids.

Uniprot Accession IDs

• O15173
• Q569H1

Gene Name

• PGRMC2

Ensembl ID

• ENST00000296425
• ENSP00000296425
• ENSG00000164040
• ENST00000520121
• ENSP00000429301
• ENST00000613358
• ENSP00000481886

Symbol

• DG6
• PMBP
• DG6
• PMBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.96
drug perturbation	0.87
ligand (protein) perturbation	0.83
microRNA	0.83

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-associated Progesterone Receptor Component 2

Protein / Receptor / Membrane-associated Progesterone Receptor Component 2

DTO Classes

Protein / Signaling / Membrane-associated Progesterone Receptor Component 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (37)

Explore Interacting Targets

1 – 10 of 37

• See Interactions on String-DB

SERBP1

Tbio

Novelty:  0.03271429

Score:  0.765

Data Source:  STRINGDB

PAQR7

Tbio

Novelty:  0.00870986

Score:  0.717

Data Source:  STRINGDB

CYB5A

Tbio

Novelty:  0.00047376

Score:  0.685

Data Source:  STRINGDB

PAQR8

Tbio

Novelty:  0.05328888

Score:  0.679

Data Source:  STRINGDB

PGR

Tclin

Family:  NR

Novelty:  0.00008416

Score:  0.676

Data Source:  STRINGDB

PAQR9

Tdark

Novelty:  0.39198507

Score:  0.665

Data Source:  STRINGDB

PAQR5

Tbio

Novelty:  0.05821975

Score:  0.663

Data Source:  STRINGDB

CYP51A1

Tchem

Family:  Enzyme

Novelty:  0.00127373

Score:  0.655

Data Source:  STRINGDB

NCKAP1L

Tbio

Novelty:  0.03392474

Score:  0.636

Data Source:  STRINGDB

PAQR6

Tbio

Novelty:  0.10793454

Score:  0.63

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

WikiPathways (2)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Ciliary landscape	642 targets	WP4352_r102218
WikiPathways	Ciliary landscape	642 targets	WP4352_r102218

Name	Explore in Pharos	Explore in Source
Ciliary landscape	642 targets	WP4352_r102218
Ciliary landscape	642 targets	WP4352_r102218

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (2)

Components (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
steroid binding	Traceable Author Statement (TAS)	ProtInc
steroid hormone receptor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2	1	2		75.7
reticulocyte count	EFO_0007986	2	1	2		53.7
reticulocyte measurement	EFO_0010700	1	1	1		53.3
mean reticulocyte volume	EFO_0010701	1	1	1		35
type II diabetes mellitus	EFO_0001360	1	1	1		0.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		75.7
reticulocyte count	EFO_0007986	2		53.7
reticulocyte measurement	EFO_0010700	1		53.3
mean reticulocyte volume	EFO_0010701	1		35
type II diabetes mellitus	EFO_0001360	1		0.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Lipid-binding
Membrane
Phosphoprotein
Receptor
Reference proteome
Steroid-binding
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
mean reticulocyte volume
red blood cell distribution width
reticulocyte count
reticulocyte measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	progesterone receptor membrane component 2	VGNC:659	461483
Mouse	progesterone receptor membrane component 2	MGI:1918054	70804
Rat	progesterone receptor membrane component 2	RGD:1308804	361940
Dog	progesterone receptor membrane component 2	VGNC:44471	476084
Cow	progesterone receptor membrane component 2	VGNC:32802	534021

Species	Name	OMA	EggNOG	Inparanoid
Chimp	progesterone receptor membrane component 2
Mouse	progesterone receptor membrane component 2
Rat	progesterone receptor membrane component 2
Dog	progesterone receptor membrane component 2
Cow	progesterone receptor membrane component 2

Publication Statistics

PubMed Score 96.63

PubMed score by year

Reset Zoom

PubTator Score 28.42

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (22)

GeneRif Annotations (10)

Items per page:

10

0 of 0

PMID	Year	Title