Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Receptor for steroids.

Uniprot Accession IDs

Gene Name

PGRMC2

Ensembl ID

ENST00000296425
ENSP00000296425
ENSG00000164040
ENST00000520121
ENSP00000429301
ENST00000613358
ENSP00000481886

Symbol

DG6
PMBP
DG6
PMBP

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99

disease perturbation	0.96

drug perturbation	0.87

ligand (protein) perturbation	0.83

microRNA	0.83

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63 (req: < 5)

View Publications

Gene RIFs: 10 (req: <= 3)

View Gene RIFs

Antibodies: 254 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63 (req: >= 5)

Gene RIFs: 10 (req: > 3)

Antibodies: 254 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	2	1	2	75.7

reticulocyte count	EFO_0007986	2	1	2	53.7

reticulocyte measurement	EFO_0010700	1	1	1	53.3

mean reticulocyte volume	EFO_0010701	1	1	1	35

type II diabetes mellitus	EFO_0001360	1	1	1	0.8

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
red blood cell distribution width	EFO_0005192	2	75.7

reticulocyte count	EFO_0007986	2	53.7

reticulocyte measurement	EFO_0010700	1	53.3

mean reticulocyte volume	EFO_0010701	1	35

type II diabetes mellitus	EFO_0001360	1	0.8

Beta Count

Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID
Chimp	progesterone receptor membrane component 2	VGNC:659	461483

Mouse	progesterone receptor membrane component 2	MGI:1918054	70804

Rat	progesterone receptor membrane component 2	RGD:1308804	361940

Dog	progesterone receptor membrane component 2	VGNC:44471	476084

Cow	progesterone receptor membrane component 2	VGNC:32802	534021

Species	Name	OMA	EggNOG	Inparanoid
Chimp	progesterone receptor membrane component 2

Mouse	progesterone receptor membrane component 2

Rat	progesterone receptor membrane component 2

Dog	progesterone receptor membrane component 2

Cow	progesterone receptor membrane component 2

Protein Structure (0 Structures, 1 AlphaFold Model)

Pathways (2)

WikiPathways (2)

Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Ciliary landscape	642 targets	WP4352_r102218

WikiPathways	Ciliary landscape	642 targets	WP4352_r102218

Name	Explore in Pharos	Explore in Source
Ciliary landscape	642 targets	WP4352_r102218

Ciliary landscape	642 targets	WP4352_r102218

Gene Ontology Terms (5)

Functions (2)

Components (3)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
steroid binding	Traceable Author Statement (TAS)	ProtInc

steroid hormone receptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (37)

1 – 10 of 37

See Interactions on String-DB

SERBP1

Tbio

Novelty: 0.03271429

Score: 0.765

Data Source: STRINGDB

PAQR7

Tbio

Novelty: 0.00870986

Score: 0.717

Data Source: STRINGDB

CYB5A

Tbio

Novelty: 0.00047376

Score: 0.685

Data Source: STRINGDB

PAQR8

Tbio

Novelty: 0.05328888

Score: 0.679

Data Source: STRINGDB

PGR

Tclin

Family: NR

Novelty: 0.00008416

Score: 0.676

Data Source: STRINGDB

PAQR9

Tdark

Novelty: 0.39198507

Score: 0.665

Data Source: STRINGDB

PAQR5

Tbio

Novelty: 0.05821975

Score: 0.663

Data Source: STRINGDB

CYP51A1

Tchem

Family: Enzyme

Novelty: 0.00127373

Score: 0.655

Data Source: STRINGDB

NCKAP1L

Tbio

Novelty: 0.03392474

Score: 0.636

Data Source: STRINGDB

PAQR6

Tbio

Novelty: 0.10793454

Score: 0.63

Data Source: STRINGDB

Publication Statistics

PubMed Score 96.63

PubMed score by year

PubTator Score 28.42

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword

No Header	No Header
Alternative splicing

Complete proteome

Lipid-binding

Membrane

Phosphoprotein

Receptor

Reference proteome

Steroid-binding

Transmembrane

Transmembrane helix

GWAS Trait

MGI Phenotype

No Header	No Header
embryo phenotype

endocrine/exocrine gland phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

mortality/aging

reproductive system phenotype