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Tbio
PGRMC2
Membrane-associated progesterone receptor component 2

Protein Classes
Protein Summary
Description
Receptor for steroids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296425
  • ENSP00000296425
  • ENSG00000164040
  • ENST00000520121
  • ENSP00000429301
  • ENST00000613358
  • ENSP00000481886

Symbol
  • DG6
  • PMBP
  • DG6
  • PMBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.96
drug perturbation
0.87
ligand (protein) perturbation
0.83
microRNA
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
75.7
reticulocyte count
2
1
2
53.7
reticulocyte measurement
1
1
1
53.3
mean reticulocyte volume
1
1
1
35
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
75.7
reticulocyte count
2
53.7
reticulocyte measurement
1
53.3
mean reticulocyte volume
1
35
1
0.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor membrane component 2
VGNC:659
461483
Mouse
MGI:1918054
70804
Rat
RGD:1308804
361940
Dog
progesterone receptor membrane component 2
VGNC:44471
476084
Cow
progesterone receptor membrane component 2
VGNC:32802
534021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor membrane component 2
Mouse
Rat
Dog
progesterone receptor membrane component 2
Cow
progesterone receptor membrane component 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15173-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (37)
1 – 10 of 37
SERBP1
Tbio
Novelty:  0.03271429
Score:  0.765
Data Source:  STRINGDB
PAQR7
Tbio
Novelty:  0.00870986
Score:  0.717
Data Source:  STRINGDB
CYB5A
Tbio
Novelty:  0.00047376
Score:  0.685
Data Source:  STRINGDB
PAQR8
Tbio
Novelty:  0.05328888
Score:  0.679
Data Source:  STRINGDB
PGR
Tclin
Family:  NR
Novelty:  0.00008416
Score:  0.676
Data Source:  STRINGDB
PAQR9
Tdark
Novelty:  0.39198507
Score:  0.665
Data Source:  STRINGDB
PAQR5
Tbio
Novelty:  0.05821975
Score:  0.663
Data Source:  STRINGDB
CYP51A1
Tchem
Family:  Enzyme
Novelty:  0.00127373
Score:  0.655
Data Source:  STRINGDB
NCKAP1L
Tbio
Novelty:  0.03392474
Score:  0.636
Data Source:  STRINGDB
PAQR6
Tbio
Novelty:  0.10793454
Score:  0.63
Data Source:  STRINGDB
Publication Statistics
PubMed Score  96.63

PubMed score by year
PubTator Score  28.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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