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Tchem
TRIM24
Transcription intermediary factor 1-alpha

Protein Summary
Description
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343526
  • ENSP00000340507
  • ENSG00000122779
  • ENST00000415680
  • ENSP00000390829

Symbol
  • RNF82
  • TIF1
  • TIF1A
  • PTC6
  • TF1A
  • TIF1
  • RNF82
  • TIF1A
  • hTIF1
  • TIF1ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor perturbation
0.98
co-expressed gene
0.97
hub protein
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.73   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.73   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (26)
1 – 10 of 26
CHEMBL3774575
chemical structure image
CHEMBL3769965
chemical structure image
CHEMBL3770456
chemical structure image
CHEMBL3770259
chemical structure image
CHEMBL3771002
chemical structure image
CHEMBL3769887
chemical structure image
CHEMBL3775073
chemical structure image
CHEMBL3775853
chemical structure image
CHEMBL3774766
chemical structure image
CHEMBL3775901
chemical structure image
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (188)
1 – 10 of 188
ZNF264
Tdark
Family: TF
Novelty: 0.32927591
p_int: 0.99996793
p_ni: 0.00003207
Score: 0.173
Data Source: BioPlex,STRINGDB
ZNF483
Tdark
Family: TF
Novelty: 0.39891191
p_int: 0.999964524
p_ni: 0.000035476
Score: 0.165
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999902062
p_ni: 0.000097938
Data Source: BioPlex
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.999760997
p_ni: 0.000239003
Score: 0.152
Data Source: BioPlex,STRINGDB
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.999564599
p_ni: 0.000435401
Data Source: BioPlex
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.999431264
p_ni: 0.000568736
Data Source: BioPlex
ZNF695
Tdark
Family: TF
Novelty: 0.37164664
p_int: 0.996864299
p_ni: 0.003135701
Score: 0.211
Data Source: BioPlex,STRINGDB
ZNF287
Tdark
Family: TF
Novelty: 1.01445884
p_int: 0.996571334
p_ni: 0.003428666
Data Source: BioPlex
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.996563335
p_ni: 0.003436665
Data Source: BioPlex
QPRT
Tbio
Family: Enzyme
Novelty: 0.00781554
p_int: 0.995078163
p_ni: 0.004921837
Data Source: BioPlex
Publication Statistics
PubMed Score  195.73

PubMed score by year
PubTator Score  104.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer