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Tbio
POLR1C
DNA-directed RNA polymerases I and III subunit RPAC1

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304004
  • ENSP00000307212
  • ENSG00000171453
  • ENST00000372389
  • ENSP00000361465
  • ENST00000607635
  • ENSP00000496683
  • ENST00000642195
  • ENSP00000496044

Symbol
  • POLR1E
  • AC40
  • RPA5
  • TCS3
  • HLD11
  • RPA39
  • RPA40
  • RPAC1
  • RPC40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
protein complex
1
histone modification site profile
0.84
kinase perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
24.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
24.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit C
VGNC:8725
736609
Macaque
RNA polymerase I subunit C
700727
Mouse
MGI:103288
20016
Rat
RGD:1309689
301246
Dog
RNA polymerase I and III subunit C
VGNC:44790
474912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I and III subunit C
Macaque
RNA polymerase I subunit C
Mouse
Rat
Dog
RNA polymerase I and III subunit C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15160-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Epigenetic regulation of gene expression
Gene expression (Transcription)
Immune System
Protein-Protein Interactions (442)
1 – 10 of 442
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.999999995
p_ni: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ROCK2
Tclin
Family: Kinase
Novelty: 0.00242311
p_int: 0.999999973
p_ni: 2.7e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
POLR3G
Tbio
Family: Enzyme
Novelty: 0.04923071
p_int: 0.999999938
p_ni: 1.9e-8
p_wrong: 4.3e-8
Score: 0.991
Data Source: BioPlex,STRINGDB
CRCP
Tbio
Family: Enzyme
Novelty: 0.01111812
p_int: 0.999999902
p_ni: 3.6e-8
p_wrong: 6.2e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
p_int: 0.999999823
p_ni: 1.77e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 0.99999978
p_ni: 2.2e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
POLR3C
Tbio
Family: Enzyme
Novelty: 0.05778457
p_int: 0.999999776
p_ni: 2.24e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3H
Tbio
Family: Enzyme
Novelty: 0.16483597
p_int: 0.999999726
p_ni: 2.74e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CD3EAP
Tbio
Family: Enzyme
Novelty: 0.04978272
p_int: 0.999999632
p_ni: 3.53e-7
p_wrong: 1.5e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
POLR1E
Tbio
Family: Enzyme
Novelty: 0.09991103
p_int: 0.999999232
p_ni: 7.67e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.21

PubMed score by year
PubTator Score  23.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer