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Tbio
ZBTB7B
Zinc finger and BTB domain-containing protein 7B

Protein Summary
Description
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, act ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292176
  • ENSP00000292176
  • ENSG00000160685
  • ENST00000368426
  • ENSP00000357411
  • ENST00000417934
  • ENSP00000406286
  • ENST00000535420
  • ENSP00000438647

Symbol
  • ZBTB15
  • ZFP67
  • ZNF857B
  • CKROX
  • THPOK
  • ZFP67
  • ZBTB15
  • ZFP-67
  • c-KROX
  • hcKROX
  • ZNF857B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
virus perturbation
0.88
protein domain
0.85
transcription factor
0.85
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.04   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.04   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (35)
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
WikiPathways
Ectoderm Differentiation
Name
Explore in Pharos
Explore in Source
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Ectoderm Differentiation
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
P4HA3
Tbio
Family: Enzyme
Novelty: 0.04334371
p_int: 1
Score: 0.255
Data Source: BioPlex,STRINGDB
CDCP1
Tbio
Novelty: 0.01707638
Score: 0.919
Data Source: STRINGDB
RUNX3
Tbio
Family: TF
Novelty: 0.00175224
Score: 0.874
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00087325
Score: 0.873
Data Source: STRINGDB
IMP4
Tdark
Score: 0.686
Data Source: STRINGDB
GZMB
Tchem
Family: Enzyme
Novelty: 0.00040843
Score: 0.685
Data Source: STRINGDB
CD4
Tclin
Novelty: 0.00001541
Score: 0.652
Data Source: STRINGDB
CD8A
Tbio
Novelty: 0.00003113
Score: 0.63
Data Source: STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00113895
Score: 0.611
Data Source: STRINGDB
TBX21
Tbio
Family: TF
Novelty: 0.00116251
Score: 0.593
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.04

PubMed score by year
PubTator Score  34.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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