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Tdark
BET1
BET1 homolog

Protein Summary
Description
Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity). This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222547
  • ENSP00000222547
  • ENSG00000105829
  • ENST00000433727
  • ENSP00000391228

Symbol
  • HBET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
interacting protein
0.82
histone modification site profile
0.8
transcription factor binding site profile
0.78
cellular component
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
3
2
6
75.9
heart rate response to recovery post exercise
5
2
5
57.6
heart rate
1
1
1
12.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
6
75.9
heart rate response to recovery post exercise
5
57.6
heart rate
1
12.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Bet1 golgi vesicular membrane trafficking protein
700492
Mouse
MGI:1343104
12068
Rat
RGD:2203
29631
Cow
Bet1 golgi vesicular membrane trafficking protein
VGNC:26475
616526
Opossum
Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Bet1 golgi vesicular membrane trafficking protein
Mouse
Rat
Cow
Bet1 golgi vesicular membrane trafficking protein
Opossum
Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15155-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (200)
1 – 10 of 200
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.999922949
p_ni:  0.000076954
p_wrong:  9.7e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999874073
p_ni:  0.000125869
p_wrong:  5.8e-8
Score:  0.926
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.9649414
p_ni:  0.034634219
p_wrong:  0.000424381
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.963180199
p_ni:  0.036324633
p_wrong:  0.000495168
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.929150652
p_ni:  0.05874046
p_wrong:  0.012108889
Data Source:  BioPlex
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.927043188
p_ni:  0.058027908
p_wrong:  0.014928903
Data Source:  BioPlex
HAUS1
Tbio
Novelty:  0.11356375
p_int:  0.884023399
p_ni:  0.11541869
p_wrong:  0.000557911
Score:  0.173
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.865997253
p_ni:  0.001801338
p_wrong:  0.132201409
Data Source:  BioPlex
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.864841576
p_ni:  0.008981119
p_wrong:  0.126177305
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.85609226
p_ni:  0.002282381
p_wrong:  0.141625359
Data Source:  BioPlex
Publication Statistics
PubMed Score  51.74

PubMed score by year
PubTator Score  126.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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