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Tchem
MDM4
Protein Mdm4

Protein Summary
Description
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367182
  • ENSP00000356150
  • ENSG00000198625
  • ENST00000367183
  • ENSP00000356151
  • ENST00000454264
  • ENSP00000396840

Symbol
  • MDMX
  • HDMX
  • MDMX
  • MRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
microRNA
0.91
transcription factor binding site profile
0.91
kinase
0.87
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.52   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 631   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.52   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
4
4
3.5
94.7
mathematical ability
4
3
4
89.5
4
2
0
1.1
87.8
household income
2
5
6
86.2
forced expiratory volume
2
2
1
14.6
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3.5
94.7
mathematical ability
4
89.5
0
1.1
87.8
household income
6
86.2
forced expiratory volume
1
14.6
81.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MDM4, p53 regulator
VGNC:8390
457658
Macaque
MDM4, p53 regulator
699563
Mouse
MGI:107934
17248
Rat
RGD:1309306
304798
Dog
MDM4, p53 regulator
VGNC:43107
478939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MDM4, p53 regulator
Macaque
MDM4, p53 regulator
Mouse
Rat
Dog
MDM4, p53 regulator
Protein Structure (24 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15151-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 24
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (242)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (123)
1 – 10 of 123
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.999999992
p_ni:  8e-9
Score:  0.488
Data Source:  BioPlex,STRINGDB
FAM193A
Tdark
Novelty:  0.35264727
p_int:  0.999999798
p_ni:  2e-7
p_wrong:  1e-9
Score:  0.39
Data Source:  BioPlex,STRINGDB
PELI1
Tbio
Family:  Enzyme
Novelty:  0.0479662
p_int:  0.999999608
p_ni:  1.14e-7
p_wrong:  2.78e-7
Score:  0.624
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.999995436
p_ni:  0.000004558
p_wrong:  7e-9
Score:  0.493
Data Source:  BioPlex,STRINGDB
CCNDBP1
Tbio
Novelty:  0.01527762
p_int:  0.999985667
p_ni:  0.000014333
Score:  0.183
Data Source:  BioPlex,STRINGDB
PPARD
Tchem
Family:  NR
Novelty:  0.00271873
p_int:  0.999974694
p_ni:  0.000025194
p_wrong:  1.12e-7
Score:  0.755
Data Source:  BioPlex,STRINGDB
SPATA46
Tdark
Novelty:  0.327066
p_int:  0.999970569
p_ni:  0.000029369
p_wrong:  6.3e-8
Score:  0.798
Data Source:  BioPlex,STRINGDB
ASRGL1
Tbio
Family:  Enzyme
Novelty:  0.02377734
p_int:  0.9997281
p_ni:  0.000271838
p_wrong:  6.2e-8
Score:  0.388
Data Source:  BioPlex,STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
p_int:  0.999136292
p_ni:  0.000863708
Score:  0.809
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  322.52

PubMed score by year
PubTator Score  231.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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