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Tchem
MUSK
Muscle, skeletal receptor tyrosine-protein kinase

Protein Summary
Description
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000189978
  • ENSP00000189978
  • ENSG00000030304
  • ENST00000374448
  • ENSP00000363571

Symbol
  • CMS9
  • FADS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
biological process
0.82
trait
0.75
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.21   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.21   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
84.7
Pathways (2)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (120)
1 – 10 of 120
ADAM30
Tdark
Family: Enzyme
Novelty: 0.25395428
p_int: 0.999999779
p_ni: 2.18e-7
p_wrong: 2e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.989026376
p_ni: 0.010973624
Score: 0.247
Data Source: BioPlex,STRINGDB
RBSN
Tbio
Novelty: 0.0046123
p_int: 0.872421843
p_ni: 0.127296834
p_wrong: 0.000281323
Score: 0.352
Data Source: BioPlex,STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.997
Data Source: Reactome,STRINGDB
RAPSN
Tbio
Novelty: 0.00565077
Score: 0.997
Data Source: STRINGDB
LRP4
Tbio
Novelty: 0.01336125
Score: 0.991
Data Source: Reactome,STRINGDB
DOK7
Tbio
Novelty: 0.01360545
Score: 0.99
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.966
Data Source: STRINGDB
COLQ
Tbio
Family: Enzyme
Novelty: 0.01414634
Score: 0.966
Data Source: STRINGDB
CHRNB1
Tclin
Family: IC
Novelty: 0.04777051
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  725.21

PubMed score by year
PubTator Score  298.66

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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