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Tchem
MUSK
Muscle, skeletal receptor tyrosine-protein kinase

Protein Summary
Description
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000189978
  • ENSP00000189978
  • ENSG00000030304
  • ENST00000374448
  • ENSP00000363571

Symbol
  • CMS9
  • FADS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
biological process
0.82
trait
0.75
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.52   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.52   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (120)
ADAM30
Tdark
Family:  Enzyme
Novelty:  0.25395428
p_int:  0.999999779
p_ni:  2.18e-7
p_wrong:  2e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
p_int:  0.989026376
p_ni:  0.010973624
Score:  0.247
Data Source:  BioPlex,STRINGDB
RBSN
Tbio
Novelty:  0.0046123
p_int:  0.872421843
p_ni:  0.127296834
p_wrong:  0.000281323
Score:  0.352
Data Source:  BioPlex,STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.997
Data Source:  Reactome,STRINGDB
RAPSN
Tbio
Novelty:  0.00565077
Score:  0.997
Data Source:  STRINGDB
LRP4
Tbio
Novelty:  0.01336125
Score:  0.991
Data Source:  Reactome,STRINGDB
DOK7
Tbio
Novelty:  0.01360545
Score:  0.99
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.966
Data Source:  STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
Score:  0.966
Data Source:  STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
94
eosinophil percentage of leukocytes
2
2
2
92.6
central corneal thickness
2
1
0
2.8
73.7
heel bone mineral density
2
2
3
73.2
sum of eosinophil and basophil counts
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
94
eosinophil percentage of leukocytes
2
92.6
central corneal thickness
0
2.8
73.7
heel bone mineral density
3
73.2
sum of eosinophil and basophil counts
1
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
muscle associated receptor tyrosine kinase
VGNC:10127
464653
Macaque
muscle associated receptor tyrosine kinase
709397
Mouse
MGI:103581
18198
Rat
RGD:3211
81725
Horse
muscle associated receptor tyrosine kinase
VGNC:20446
100058619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
muscle associated receptor tyrosine kinase
Macaque
muscle associated receptor tyrosine kinase
Mouse
Rat
Horse
muscle associated receptor tyrosine kinase
Publication Statistics
PubMed Score 745.52
PubMed score by year
PubTator Score 298.66
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title