Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which ...more

Uniprot Accession IDs

Gene Name

MUSK

Ensembl ID

ENST00000189978
ENSP00000189978
ENSG00000030304
ENST00000374448
ENSP00000363571

Symbol

CMS9
FADS

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1

molecular function	0.98

biological process	0.82

trait	0.75

kinase perturbation	0.71

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.21 (req: < 5)

View Publications

Gene RIFs: 42 (req: <= 3)

View Gene RIFs

Antibodies: 447 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 725.21 (req: >= 5)

Gene RIFs: 42 (req: > 3)

Antibodies: 447 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (6)

1 – 6 of 6

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	3		84.7

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3		84.7

Beta Count

Odds Ratio

Pathways (2)

Reactome (2)

ECM proteoglycans (R-HSA-3000178)

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Items per page:

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178

Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
ECM proteoglycans	56 targets	R-HSA-3000178

Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (26)

Functions (6)

Components (6)

Processes (14)

Items per page:

1 – 6 of 6

GO Term	Evidence	Assigned by
transmembrane receptor protein tyrosine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

transmembrane signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Wnt-protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

protein tyrosine kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (120)

1 – 10 of 120

See Interactions on String-DB

ADAM30

Tdark

Family: Enzyme

Novelty: 0.25395428

p_int: 0.999999779

p_ni: 2.18e-7

p_wrong: 2e-9

Score: 0.215

Data Source: BioPlex,STRINGDB

DNAJC13

Tbio

Novelty: 0.03251995

p_int: 0.989026376

p_ni: 0.010973624

Score: 0.247

Data Source: BioPlex,STRINGDB

RBSN

Tbio

Novelty: 0.0046123

p_int: 0.872421843

p_ni: 0.127296834

p_wrong: 0.000281323

Score: 0.352

Data Source: BioPlex,STRINGDB

AGRN

Tbio

Novelty: 0.00156441

Score: 0.997

Data Source: Reactome,STRINGDB

RAPSN

Tbio

Novelty: 0.00565077

Score: 0.997

Data Source: STRINGDB

LRP4

Tbio

Novelty: 0.01336125

Score: 0.991

Data Source: Reactome,STRINGDB

DOK7

Tbio

Novelty: 0.01360545

Score: 0.99

Data Source: STRINGDB

DVL1

Tchem

Novelty: 0.00356876

Score: 0.966

Data Source: STRINGDB

COLQ

Tbio

Family: Enzyme

Novelty: 0.01414634

Score: 0.966

Data Source: STRINGDB

CHRNB1

Tclin

Family: IC

Novelty: 0.04777051

Score: 0.958

Data Source: STRINGDB

Publication Statistics

PubMed Score 725.21

PubMed score by year

PubTator Score 298.66

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword


Alternative splicing

ATP-binding

Cell junction

Cell membrane

Complete proteome

Congenital myasthenic syndrome

Developmental protein

Differentiation

Disease mutation

Disulfide bond

GWAS Trait


heel bone mineral density

MGI Phenotype


behavior/neurological phenotype

cellular phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

integument phenotype

mortality/aging

muscle phenotype

nervous system phenotype

respiratory system phenotype

skeleton phenotype