MUSK
Muscle, skeletal receptor tyrosine-protein kinase
Protein Summary
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which ...more
- ENST00000189978
- ENSP00000189978
- ENSG00000030304
- ENST00000374448
- ENSP00000363571
- CMS9
- FADS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
biological process | 0.82 | ||
trait | 0.75 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 745.52 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 447 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 745.52 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 447 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (120)
ADAM30
Family: Enzyme
Novelty: 0.25395428
p_int: 0.999999779
p_ni: 2.18e-7
p_wrong: 2e-9
Score: 0.215
Data Source: BioPlex,STRINGDB
DNAJC13
Novelty: 0.03251995
p_int: 0.989026376
p_ni: 0.010973624
Score: 0.247
Data Source: BioPlex,STRINGDB
RBSN
Novelty: 0.0046123
p_int: 0.872421843
p_ni: 0.127296834
p_wrong: 0.000281323
Score: 0.352
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (6)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 2 | 3 | 94 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 92.6 | |||||
central corneal thickness | 2 | 1 | 0 | 2.8 | 73.7 | ||||
heel bone mineral density | 2 | 2 | 3 | 73.2 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 68.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 94 | |||||
eosinophil percentage of leukocytes | 2 | 92.6 | |||||
central corneal thickness | 0 | 2.8 | 73.7 | ||||
heel bone mineral density | 3 | 73.2 | |||||
sum of eosinophil and basophil counts | 1 | 68.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | muscle associated receptor tyrosine kinase | VGNC:10127 | 464653 | |||||
Macaque | muscle associated receptor tyrosine kinase | 709397 | ||||||
Mouse | MGI:103581 | 18198 | ||||||
Rat | RGD:3211 | 81725 | ||||||
Horse | muscle associated receptor tyrosine kinase | VGNC:20446 | 100058619 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | muscle associated receptor tyrosine kinase | |||||
Macaque | muscle associated receptor tyrosine kinase | |||||
Mouse | ||||||
Rat | ||||||
Horse | muscle associated receptor tyrosine kinase | |||||
Publication Statistics
PubMed Score 745.52
PubMed score by year
PubTator Score 298.66
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (55)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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