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Tbio
ARPC3
Actin-related protein 2/3 complex subunit 3

Protein Summary
Description
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228825
  • ENSP00000228825
  • ENSG00000111229

Symbol
  • ARC21
  • ARC21
  • p21-Arc
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.95
co-expressed gene
0.85
transcription factor binding site profile
0.85
virus perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
71.3
1
1
1
51.7
1
1
1
51.7
body height
1
1
1
48.5
risk-taking behaviour
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
71.3
1
51.7
1
51.7
body height
1
48.5
risk-taking behaviour
1
21.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 3
VGNC:10574
738738
Macaque
actin related protein 2/3 complex subunit 3
709199
Mouse
MGI:1928375
56378
Rat
RGD:1311985
288669
Horse
actin related protein 2/3 complex subunit 3
VGNC:15538
100058336
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 3
Macaque
actin related protein 2/3 complex subunit 3
Mouse
Rat
Horse
actin related protein 2/3 complex subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (254)
1 – 10 of 254
GALT
Tbio
Family:  Enzyme
Novelty:  0.0120291
p_int:  0.999981693
p_ni:  0.000018267
p_wrong:  4e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.999944054
p_ni:  0.000055946
Score:  0.987
Data Source:  BioPlex,STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
p_int:  0.999834852
p_ni:  0.000165148
Score:  0.678
Data Source:  BioPlex,STRINGDB
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.999584127
p_ni:  0.000415871
p_wrong:  2e-9
Score:  0.638
Data Source:  BioPlex,STRINGDB
DOCK7
Tbio
Novelty:  0.03425586
p_int:  0.999460304
p_ni:  0.000539696
Score:  0.546
Data Source:  BioPlex,STRINGDB
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.997547853
p_ni:  0.002452146
Data Source:  BioPlex
ARPC5
Tbio
Novelty:  0.03434234
p_int:  0.99666982
p_ni:  0.00333018
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.995471451
p_ni:  0.004528549
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
p_int:  0.975824475
p_ni:  0.024175525
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
p_int:  0.97525584
p_ni:  0.02474416
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.85

PubMed score by year
PubTator Score  14.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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