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Tbio
ARPC3
Actin-related protein 2/3 complex subunit 3

Protein Summary
Description
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228825
  • ENSP00000228825
  • ENSG00000111229

Symbol
  • ARC21
  • ARC21
  • p21-Arc
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.95
co-expressed gene
0.85
transcription factor binding site profile
0.85
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: < 5)
View Publications
Gene RIFs: 4   (req: <= 3)
View Gene RIFs
Antibodies: 227   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (30)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
533 targets
R-HSA-422475
Reactome
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
EPH-Ephrin signaling
92 targets
R-HSA-2682334
Reactome
EPHB-mediated forward signaling
34 targets
R-HSA-3928662
Name
Explore in Pharos
Explore in Source
Axon guidance
533 targets
R-HSA-422475
Clathrin-mediated endocytosis
143 targets
R-HSA-8856828
Developmental Biology
1055 targets
R-HSA-1266738
EPH-Ephrin signaling
92 targets
R-HSA-2682334
EPHB-mediated forward signaling
34 targets
R-HSA-3928662
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
structural constituent of cytoskeleton
Inferred from Direct Assay (IDA)
FlyBase
actin binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (254)
1 – 10 of 254
GALT
Tbio
Family: Enzyme
Novelty: 0.00883448
p_int: 0.999981693
p_ni: 0.000018267
p_wrong: 4e-8
Score: 0.228
Data Source: BioPlex,STRINGDB
ACTR3B
Tbio
Novelty: 0.09881697
p_int: 0.999944054
p_ni: 0.000055946
Score: 0.987
Data Source: BioPlex,STRINGDB
DOCK8
Tbio
Novelty: 0.00796871
p_int: 0.999834852
p_ni: 0.000165148
Score: 0.678
Data Source: BioPlex,STRINGDB
LRCH2
Tdark
p_int: 0.999584127
p_ni: 0.000415871
p_wrong: 2e-9
Score: 0.638
Data Source: BioPlex,STRINGDB
DOCK7
Tbio
Novelty: 0.05517795
p_int: 0.999460304
p_ni: 0.000539696
Score: 0.546
Data Source: BioPlex,STRINGDB
CLUH
Tbio
Novelty: 0.13787182
p_int: 0.997547853
p_ni: 0.002452146
Data Source: BioPlex
ARPC5
Tbio
Novelty: 0.08405086
p_int: 0.99666982
p_ni: 0.00333018
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3
Tbio
Novelty: 0.03429716
p_int: 0.995471451
p_ni: 0.004528549
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC2
Tbio
Novelty: 0.04147436
p_int: 0.975824475
p_ni: 0.024175525
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.01032806
p_int: 0.97525584
p_ni: 0.02474416
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.72

PubMed score by year
PubTator Score  14.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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