Tbio ARPC3 Actin-related protein 2/3 complex subunit 3

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 3

Protein Summary

Description

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• O15145
• O00554

Gene Name

• ARPC3

Ensembl ID

• ENST00000228825
• ENSP00000228825
• ENSG00000111229

Symbol

• ARC21
• ARC21
• p21-Arc

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.95
co-expressed gene	0.85
transcription factor binding site profile	0.85
virus perturbation	0.79

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	2	1	2		71.3
schizophrenia	EFO_0000692	1	1	1		51.7
bipolar disorder	EFO_0000289	1	1	1		51.7
body height	EFO_0004339	1	1	1		48.5
risk-taking behaviour	EFO_0008579	1	1	1		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	2		71.3
schizophrenia	EFO_0000692	1		51.7
bipolar disorder	EFO_0000289	1		51.7
body height	EFO_0004339	1		48.5
risk-taking behaviour	EFO_0008579	1		21.5

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Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	actin related protein 2/3 complex subunit 3	VGNC:10574	738738
Macaque	actin related protein 2/3 complex subunit 3		709199
Mouse	actin related protein 2/3 complex, subunit 3	MGI:1928375	56378
Rat	actin related protein 2/3 complex, subunit 3	RGD:1311985	288669
Horse	actin related protein 2/3 complex subunit 3	VGNC:15538	100058336

Species	Name	OMA	EggNOG	Inparanoid
Chimp	actin related protein 2/3 complex subunit 3
Macaque	actin related protein 2/3 complex subunit 3
Mouse	actin related protein 2/3 complex, subunit 3
Rat	actin related protein 2/3 complex, subunit 3
Horse	actin related protein 2/3 complex subunit 3

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O15145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)

Reactome (15)

KEGG (7)

PathwayCommons (7)

WikiPathways (1)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPHB-mediated forward signaling	34 targets	R-HSA-3928662

Gene Ontology Terms (19)

Functions (2)

Components (11)

Processes (6)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
structural constituent of cytoskeleton	Inferred from Direct Assay (IDA)	FlyBase
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (254)

Explore Interacting Targets

1 – 10 of 254

• See Interactions on String-DB

GALT

Tbio

Family:  Enzyme

Novelty:  0.0120291

p_int:  0.999981693

p_ni:  0.000018267

p_wrong:  4e-8

Score:  0.228

Data Source:  BioPlex,STRINGDB

ACTR3B

Tbio

Novelty:  0.06033214

p_int:  0.999944054

p_ni:  0.000055946

Score:  0.987

Data Source:  BioPlex,STRINGDB

DOCK8

Tbio

Novelty:  0.0067047

p_int:  0.999834852

p_ni:  0.000165148

Score:  0.678

Data Source:  BioPlex,STRINGDB

LRCH2

Tdark

Novelty:  1.90908316

p_int:  0.999584127

p_ni:  0.000415871

p_wrong:  2e-9

Score:  0.638

Data Source:  BioPlex,STRINGDB

DOCK7

Tbio

Novelty:  0.03425586

p_int:  0.999460304

p_ni:  0.000539696

Score:  0.546

Data Source:  BioPlex,STRINGDB

CLUH

Tbio

Novelty:  0.14027296

p_int:  0.997547853

p_ni:  0.002452146

Data Source:  BioPlex

ARPC5

Tbio

Novelty:  0.03434234

p_int:  0.99666982

p_ni:  0.00333018

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR3

Tchem

Novelty:  0.02112745

p_int:  0.995471451

p_ni:  0.004528549

Score:  0.999

Data Source:  BioPlex,STRINGDB

ARPC2

Tbio

Novelty:  0.02478791

p_int:  0.975824475

p_ni:  0.024175525

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACTR2

Tchem

Novelty:  0.00731489

p_int:  0.97525584

p_ni:  0.02474416

Score:  0.999

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  31.85

PubMed score by year

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PubTator Score  14.26

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
bipolar disorder
body height
body mass index
QT interval
risk-taking behaviour
schizophrenia

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype