Tbio ARPC3 Actin-related protein 2/3 complex subunit 3

Protein Summary

Description

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• O15145
• O00554

Gene Name

• ARPC3

Ensembl ID

• ENST00000228825
• ENSP00000228825
• ENSG00000111229

Symbol

• ARC21
• ARC21
• p21-Arc

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.95
co-expressed gene	0.85
transcription factor binding site profile	0.85
virus perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.53   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.53   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0