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Tbio
ARPC2
Actin-related protein 2/3 complex subunit 2

Protein Summary
Description
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved thro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295685
  • ENSP00000295685
  • ENSG00000163466
  • ENST00000315717
  • ENSP00000327137

Symbol
  • ARC34
  • ARC34
  • PRO2446
  • p34-Arc
  • PNAS-139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.77
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.32   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.32   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (31)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (22)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (228)
1 – 10 of 228
ACTR3B
Tbio
Novelty: 0.09881697
p_int: 0.999697726
p_ni: 0.000302274
Score: 0.987
Data Source: BioPlex,STRINGDB
ARPC1B
Tbio
Novelty: 0.05202587
p_int: 0.995685649
p_ni: 0.004314351
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC1A
Tbio
Novelty: 0.10861673
p_int: 0.992886368
p_ni: 0.007113631
Score: 0.999
Data Source: BioPlex,STRINGDB
ARPC3
Tbio
Novelty: 0.0428612
p_int: 0.975824475
p_ni: 0.024175525
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3
Tbio
Novelty: 0.03429716
p_int: 0.949399347
p_ni: 0.050600653
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.01032806
Score: 0.999
Data Source: STRINGDB
ARPC5L
Tdark
Novelty: 0.72650824
Score: 0.999
Data Source: STRINGDB
ARPC4
Tbio
Novelty: 0.07041459
Score: 0.999
Data Source: STRINGDB
ARPC5
Tbio
Novelty: 0.08405086
Score: 0.999
Data Source: STRINGDB
WAS
Tbio
Novelty: 0.00072185
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.32

PubMed score by year
PubTator Score  12.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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