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Tbio
ARPC1B
Actin-related protein 2/3 complex subunit 1B

Protein Summary
Description
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins sugges ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252725
  • ENSP00000252725
  • ENSG00000130429
  • ENST00000427217
  • ENSP00000403211
  • ENST00000431816
  • ENSP00000398110
  • ENST00000451682
  • ENSP00000389631
  • ENST00000455009
  • ENSP00000410238
  • ENST00000458033
  • ENSP00000388802
  • ENST00000645391
  • ENSP00000494033
  • ENST00000646101
  • ENSP00000496599

Symbol
  • ARC41
  • ARC41
  • PLTEID
  • p40-ARC
  • p41-ARC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.78
kinase perturbation
0.76
disease
0.75
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.54   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.54   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
3
3
93
dehydroepiandrosterone sulphate measurement
1
4
8
88.6
hormone measurement
2
2
3
78.7
reticulocyte count
2
1
2
78.5
lymphocyte count
1
1
1
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
3
93
dehydroepiandrosterone sulphate measurement
8
88.6
hormone measurement
3
78.7
reticulocyte count
2
78.5
lymphocyte count
1
75.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 1B
VGNC:4271
463568
Mouse
MGI:1343142
11867
Rat
RGD:2155
54227
Dog
actin related protein 2/3 complex subunit 1B
VGNC:38131
479744
Horse
actin related protein 2/3 complex subunit 1B
VGNC:15536
100059292
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 1B
Mouse
Rat
Dog
actin related protein 2/3 complex subunit 1B
Horse
actin related protein 2/3 complex subunit 1B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15143-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (117)
1 – 10 of 117
POGK
Tbio
Novelty:  0.17276635
p_int:  0.999973642
p_ni:  0.000026346
p_wrong:  1.2e-8
Score:  0.234
Data Source:  BioPlex,STRINGDB
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.9999681
p_ni:  0.0000319
Score:  0.98
Data Source:  BioPlex,STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
p_int:  0.99905129
p_ni:  0.00094871
Score:  0.568
Data Source:  BioPlex,STRINGDB
ARPC5
Tbio
Novelty:  0.03434234
p_int:  0.997662988
p_ni:  0.002337012
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
p_int:  0.996328509
p_ni:  0.003671491
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC2
Tbio
Novelty:  0.02478791
p_int:  0.995685649
p_ni:  0.004314351
Score:  0.999
Data Source:  BioPlex,STRINGDB
ACTR3
Tchem
Novelty:  0.02112745
p_int:  0.991712451
p_ni:  0.008287549
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC5L
Tdark
Novelty:  0.35566409
p_int:  0.973812492
p_ni:  0.026187508
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC4
Tbio
Novelty:  0.04212335
p_int:  0.954586869
p_ni:  0.045413131
Score:  0.999
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.54

PubMed score by year
PubTator Score  11.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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