Tbio ARPC1B Actin-related protein 2/3 complex subunit 1B

Protein Summary

Description

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• O15143
• Q9BU00

Gene Name

• ARPC1B

Ensembl ID

• ENST00000252725
• ENSP00000252725
• ENSG00000130429
• ENST00000427217
• ENSP00000403211
• ENST00000431816
• ENSP00000398110
• ENST00000451682
• ENSP00000389631
• ENST00000455009
• ENSP00000410238
• ENST00000458033
• ENSP00000388802
• ENST00000645391
• ENSP00000494033
• ENST00000646101
• ENSP00000496599

Symbol

• ARC41
• ARC41
• PLTEID
• p40-ARC
• p41-ARC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
histone modification site profile	0.78
kinase perturbation	0.76
disease	0.75
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 1b

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin-related Protein 2/3 Complex Subunit 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.03   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.03   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0