Tbio KPNA5 Importin subunit alpha-6

Protein Summary

Description

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15131
• B2RAI5
• Q86X23

Gene Name

• KPNA5

Ensembl ID

• ENST00000356348
• ENSP00000348704
• ENSG00000196911
• ENST00000368564
• ENSP00000357552

Symbol

• SRP6
• IPOA6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
histone modification site profile	0.67
cell type or tissue	0.56
small molecule perturbation	0.54
tissue	0.5

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Importin Subunit Alpha-6

DTO Classes

Protein / Transporter / Importin Subunit Alpha-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

RNMT

Tbio

Family:  Enzyme

Novelty:  0.00880207

p_int:  0.907711567

p_ni:  0.092288433

Score:  0.409

Data Source:  BioPlex,STRINGDB

SREK1IP1

Tdark

Novelty:  1.39429464

p_int:  0.893455732

p_ni:  0.106544268

Score:  0.204

Data Source:  BioPlex,STRINGDB

NOP56

Tbio

Novelty:  0.01256937

p_int:  0.884707944

p_ni:  0.115292056

Score:  0.218

Data Source:  BioPlex,STRINGDB

KBTBD4

Tdark

Novelty:  0.35515885

p_int:  0.846678666

p_ni:  0.153321334

Score:  0.258

Data Source:  BioPlex,STRINGDB

DHX40

Tdark

Family:  Enzyme

Novelty:  0.27906444

p_int:  0.785729085

p_ni:  0.214270915

Data Source:  BioPlex

NUP50

Tbio

Novelty:  0.03424725

p_int:  0.760738476

p_ni:  0.239261524

Score:  0.504

Data Source:  BioPlex,STRINGDB

IPO5

Tbio

Novelty:  0.00452607

Score:  0.954

Data Source:  STRINGDB

KPNB1

Tbio

Novelty:  0.01469696

Score:  0.954

Data Source:  STRINGDB

RAN

Tchem

Family:  Enzyme

Novelty:  0.00160888

Score:  0.809

Data Source:  STRINGDB

CSE1L

Tbio

Novelty:  0.00748892

Score:  0.804

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (10)

KEGG (1)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Host Interactions with Influenza Factors	43 targets	R-HSA-168253
Reactome	ISG15 antiviral mechanism	74 targets	R-HSA-1169408

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Disease	1105 targets	R-HSA-1643685
Host Interactions with Influenza Factors	43 targets	R-HSA-168253
ISG15 antiviral mechanism	74 targets	R-HSA-1169408

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (3)

Components (3)

Processes (2)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
nuclear localization sequence binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
nuclear import signal receptor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1	1	1		14.2
parental genotype effect measurement	EFO_0005939	1	1	1		0.5
birth weight	EFO_0004344	1	1	1		0.5

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1		14.2
parental genotype effect measurement	EFO_0005939	1		0.5
birth weight	EFO_0004344	1		0.5

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3D-structure
Complete proteome
Cytoplasm
Host-virus interaction
Polymorphism
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Reference proteome
Repeat
Transport

GWAS Trait Find Similar Targets

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birth weight
C-reactive protein measurement
parental genotype effect measurement

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	karyopherin subunit alpha 5	VGNC:7189	462963
Rat	karyopherin subunit alpha 5	RGD:1561324	294392
Dog	karyopherin subunit alpha 5	VGNC:42503	484094
Horse	karyopherin subunit alpha 5	VGNC:19507	100067045
Cow	karyopherin subunit alpha 5	VGNC:30704	783596

Species	Name	OMA	EggNOG	Inparanoid
Chimp	karyopherin subunit alpha 5
Rat	karyopherin subunit alpha 5
Dog	karyopherin subunit alpha 5
Horse	karyopherin subunit alpha 5
Cow	karyopherin subunit alpha 5

Publication Statistics

PubMed Score 14.25

PubMed score by year

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PubTator Score 6.18

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (6)

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PMID	Year	Title