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Tbio
KPNA5
Importin subunit alpha-6

Protein Summary
Description
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenz ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356348
  • ENSP00000348704
  • ENSG00000196911
  • ENST00000368564
  • ENSP00000357552

Symbol
  • SRP6
  • IPOA6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
histone modification site profile
0.67
cell type or tissue
0.56
small molecule perturbation
0.54
tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
RNMT
Tbio
Family:  Enzyme
Novelty:  0.00880207
p_int:  0.907711567
p_ni:  0.092288433
Score:  0.409
Data Source:  BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
p_int:  0.893455732
p_ni:  0.106544268
Score:  0.204
Data Source:  BioPlex,STRINGDB
NOP56
Tbio
Novelty:  0.01256937
p_int:  0.884707944
p_ni:  0.115292056
Score:  0.218
Data Source:  BioPlex,STRINGDB
KBTBD4
Tdark
Novelty:  0.35515885
p_int:  0.846678666
p_ni:  0.153321334
Score:  0.258
Data Source:  BioPlex,STRINGDB
DHX40
Tdark
Family:  Enzyme
Novelty:  0.27906444
p_int:  0.785729085
p_ni:  0.214270915
Data Source:  BioPlex
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.760738476
p_ni:  0.239261524
Score:  0.504
Data Source:  BioPlex,STRINGDB
IPO5
Tbio
Novelty:  0.00452607
Score:  0.954
Data Source:  STRINGDB
KPNB1
Tbio
Novelty:  0.01469696
Score:  0.954
Data Source:  STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.809
Data Source:  STRINGDB
CSE1L
Tbio
Novelty:  0.00748892
Score:  0.804
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Host Interactions with Influenza Factors
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Disease
Host Interactions with Influenza Factors
ISG15 antiviral mechanism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
14.2
parental genotype effect measurement
1
1
1
0.5
birth weight
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
14.2
parental genotype effect measurement
1
0.5
birth weight
1
0.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 5
VGNC:7189
462963
Rat
RGD:1561324
294392
Dog
karyopherin subunit alpha 5
VGNC:42503
484094
Horse
karyopherin subunit alpha 5
VGNC:19507
100067045
Cow
karyopherin subunit alpha 5
VGNC:30704
783596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
karyopherin subunit alpha 5
Rat
Dog
karyopherin subunit alpha 5
Horse
karyopherin subunit alpha 5
Cow
karyopherin subunit alpha 5
Publication Statistics
PubMed Score 14.25
PubMed score by year
PubTator Score 6.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title