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Tbio
NPFF
Pro-FMRFamide-related neuropeptide FF

Protein Summary
Description
Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels. This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides. These peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267017
  • ENSP00000267017
  • ENSG00000139574

Symbol
  • FMRFAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.9
tissue sample
0.67
cellular component
0.58
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
NPFFR2
Tchem
Family:  GPCR
Novelty:  0.01703886
Score:  0.994
Data Source:  Reactome,STRINGDB
NPFFR1
Tchem
Family:  GPCR
Novelty:  0.01950099
Score:  0.989
Data Source:  Reactome,STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.982
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.979
Data Source:  STRINGDB
QRFPR
Tchem
Family:  GPCR
Novelty:  0.03650642
Score:  0.966
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.962
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.961
Data Source:  STRINGDB
TAC3
Tchem
Novelty:  0.001685
Score:  0.958
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.951
Data Source:  STRINGDB
NMS
Tbio
Novelty:  0.03324369
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
82.8
heel bone mineral density
2
2
2
73.9
granulocyte percentage of myeloid white cells
1
1
1
65.7
neutrophil count
2
1
2
57.9
body mass index
1
1
1
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
82.8
heel bone mineral density
2
73.9
granulocyte percentage of myeloid white cells
1
65.7
neutrophil count
2
57.9
body mass index
1
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF-amide peptide precursor
VGNC:8476
736226
Mouse
MGI:1891708
54615
Rat
RGD:62033
60337
Horse
neuropeptide FF-amide peptide precursor [Source:HGNC Symbol;Acc:HGNC:7901]
Cow
neuropeptide FF-amide peptide precursor
VGNC:32198
281354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide FF-amide peptide precursor
Mouse
Rat
Horse
neuropeptide FF-amide peptide precursor [Source:HGNC Symbol;Acc:HGNC:7901]
Cow
neuropeptide FF-amide peptide precursor
Publication Statistics
PubMed Score 237.70
PubMed score by year
PubTator Score 63.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title