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Tbio
SCAMP2
Secretory carrier-associated membrane protein 2

Protein Classes
Protein Summary
Description
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268099
  • ENSP00000268099
  • ENSG00000140497
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
interacting protein
0.85
gene perturbation
0.76
cellular component
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
49.4
low density lipoprotein cholesterol measurement
1
1
1
31.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
49.4
low density lipoprotein cholesterol measurement
1
31.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 2
VGNC:1881
736098
Macaque
secretory carrier membrane protein 2
709720
Mouse
MGI:1346518
24044
Rat
RGD:68348
65168
Dog
secretory carrier membrane protein 2
VGNC:45891
487652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secretory carrier membrane protein 2
Macaque
secretory carrier membrane protein 2
Mouse
Rat
Dog
secretory carrier membrane protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15127-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (38)
1 – 10 of 38
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.859989146
p_ni: 0.140010535
p_wrong: 3.19e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.932
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.906
Data Source: STRINGDB
ATP5MG
Tbio
Family: Enzyme
Novelty: 0.16555751
Score: 0.83
Data Source: STRINGDB
PHB
Tbio
Novelty: 0.00178383
Score: 0.822
Data Source: STRINGDB
BCAP31
Tbio
Novelty: 0.01363316
Score: 0.81
Data Source: STRINGDB
SLC9A7
Tbio
Family: Transporter
Novelty: 0.03560989
Score: 0.747
Data Source: STRINGDB
HDDC3
Tbio
Family: Enzyme
Novelty: 0.03421685
Score: 0.719
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.706
Data Source: STRINGDB
SNAP23
Tbio
Novelty: 0.0065371
Score: 0.636
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.86

PubMed score by year
PubTator Score  9.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer