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Tbio
SCAMP1
Secretory carrier-associated membrane protein 1

Protein Classes
Protein Summary
Description
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614488
  • ENSP00000478071
  • ENSG00000085365
  • ENST00000621999
  • ENSP00000481022

Symbol
  • SCAMP
  • SCAMP
  • SCAMP37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
transcription factor binding site profile
0.95
co-expressed gene
0.91
disease perturbation
0.9
kinase perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.37   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.37   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
76.3
unipolar depression
1
1
0
1
67.6
1
1
0
1
67.6
intraocular pressure measurement
1
1
1
31.6
platelet crit
1
1
1
26.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
76.3
unipolar depression
0
1
67.6
0
1
67.6
intraocular pressure measurement
1
31.6
platelet crit
1
26.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1349480
107767
Rat
RGD:3625
29521
Dog
secretory carrier membrane protein 1
VGNC:45890
479172
Cow
secretory carrier membrane protein 1
VGNC:34315
535352
Chicken
secretory carrier membrane protein 1
CGNC:3258
416368
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
secretory carrier membrane protein 1
Cow
secretory carrier membrane protein 1
Chicken
secretory carrier membrane protein 1
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (14)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (141)
1 – 10 of 141
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.999999771
p_ni: 2.29e-7
Data Source: BioPlex
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.999997331
p_ni: 0.000002669
Score: 0.226
Data Source: BioPlex,STRINGDB
NT5E
Tchem
Family: Enzyme
Novelty: 0.00083237
p_int: 0.999952873
p_ni: 0.000047127
Data Source: BioPlex
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
p_int: 0.999944433
p_ni: 0.000055567
Score: 0.156
Data Source: BioPlex,STRINGDB
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.999757298
p_ni: 0.000242702
Data Source: BioPlex
MICA
Tbio
Novelty: 0.03965901
p_int: 0.999246308
p_ni: 0.000753692
p_wrong: 1e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.999125966
p_ni: 0.000818139
p_wrong: 0.000055896
Score: 0.205
Data Source: BioPlex,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.997861285
p_ni: 0.002138557
p_wrong: 1.58e-7
Data Source: BioPlex
RTN4
Tbio
Novelty: 0.00080371
p_int: 0.995899993
p_ni: 0.004100006
p_wrong: 1e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.995226782
p_ni: 0.004387084
p_wrong: 0.000386134
Score: 0.164
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.37

PubMed score by year
PubTator Score  40.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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