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Tbio
ANGPT2
Angiopoietin-2

Protein Summary
Description
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325203
  • ENSP00000314897
  • ENSG00000091879
  • ENST00000338312
  • ENSP00000343517
  • ENST00000629816
  • ENSP00000486858

Symbol
  • ANG2
  • AGPT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
0.83
biological process
0.8
virus perturbation
0.79
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1018.61   (req: < 5)
Gene RIFs: 382   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1018.61   (req: >= 5)
Gene RIFs: 382   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
1
4
84.2
heel bone mineral density
2
2
3
84
diastolic blood pressure
1
1
1
49
glomerular filtration rate
1
1
1
16.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
84.2
heel bone mineral density
3
84
diastolic blood pressure
1
49
glomerular filtration rate
1
16.9
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (182)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Tie2 Signaling
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Tie2 Signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.99901623
p_ni: 0.00098377
Score: 0.161
Data Source: BioPlex,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.996854511
p_ni: 0.00314548
p_wrong: 9e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.991707186
p_ni: 0.008292814
Score: 0.189
Data Source: BioPlex,STRINGDB
TEK
Tclin
Family: Kinase
Novelty: 0.00079268
Score: 0.999
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.952
Data Source: STRINGDB
KDR
Tclin
Family: Kinase
Novelty: 0.00016219
Score: 0.928
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.922
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.918
Data Source: STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00044273
Score: 0.915
Data Source: STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  1018.61

PubMed score by year
PubTator Score  838.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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