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Tchem
DEGS1
Sphingolipid delta(4)-desaturase DES1

Protein Summary
Description
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323699
  • ENSP00000316476
  • ENSG00000143753
  • ENST00000391877
  • ENSP00000375749

Symbol
  • DES1
  • MLD
  • MLD
  • DEGS
  • DES1
  • Des-1
  • FADS7
  • MIG15
  • DEGS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.97
kinase perturbation
0.88
virus perturbation
0.85
transcription factor binding site profile
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.05   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 334.05   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
CHEMBL1076555
chemical structure image
RBM2-1B
chemical structure image
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
delta 4-desaturase, sphingolipid 1
VGNC:8250
457770
Macaque
delta 4-desaturase, sphingolipid 1
702128
Mouse
MGI:1097711
13244
Rat
RGD:70917
58970
Dog
delta 4-desaturase, sphingolipid 1
VGNC:49678
490395
Species
Name
OMA
EggNOG
Inparanoid
Chimp
delta 4-desaturase, sphingolipid 1
Macaque
delta 4-desaturase, sphingolipid 1
Mouse
Rat
Dog
delta 4-desaturase, sphingolipid 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15121-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of lipids
Neutrophil degranulation
Protein-Protein Interactions (171)
1 – 10 of 171
C4orf3
Tbio
Novelty: 0.05950373
p_int: 0.997711522
p_ni: 0.002288478
Data Source: BioPlex
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.988515747
p_ni: 0.011484248
p_wrong: 5e-9
Data Source: BioPlex
CPLX2
Tbio
Novelty: 0.01821493
p_int: 0.983074038
p_ni: 0.016925962
Score: 0.188
Data Source: BioPlex,STRINGDB
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.976960884
p_ni: 0.023039099
p_wrong: 1.8e-8
Data Source: BioPlex
CLEC2B
Tbio
Novelty: 0.06581244
p_int: 0.967046759
p_ni: 0.032702581
p_wrong: 0.00025066
Data Source: BioPlex
TGFA
Tbio
Novelty: 0.00216159
p_int: 0.929132862
p_ni: 0.06889531
p_wrong: 0.001971828
Data Source: BioPlex
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.918153044
p_ni: 0.081846807
p_wrong: 1.49e-7
Score: 0.9
Data Source: BioPlex,STRINGDB
COX4I1
Tbio
Family: Enzyme
Novelty: 0.00208873
p_int: 0.905278798
p_ni: 0.08984757
p_wrong: 0.004873633
Data Source: BioPlex
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.89233909
p_ni: 0.107655942
p_wrong: 0.000004968
Data Source: BioPlex
CD79A
Tbio
Novelty: 0.00118942
p_int: 0.882156118
p_ni: 0.117840047
p_wrong: 0.000003834
Data Source: BioPlex
Publication Statistics
PubMed Score  334.05

PubMed score by year
PubTator Score  187.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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