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Tbio
TBX3
T-box transcription factor TBX3

Protein Summary
Description
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257566
  • ENSP00000257566
  • ENSG00000135111
  • ENST00000349155
  • ENSP00000257567

Symbol
  • UMS
  • XHL
  • TBX3-ISO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.9
molecular function
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.93   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.93   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
65
2
1
0
1.1
52.3
lower urinary tract symptom
2
1
0
1.1
52.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
65
0
1.1
52.3
lower urinary tract symptom
0
1.1
52.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box 3
VGNC:5613
740308
Macaque
T-box 3
713740
Mouse
MGI:98495
21386
Rat
RGD:735203
353305
Dog
T-box 3
VGNC:47174
477494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box 3
Macaque
T-box 3
Mouse
Rat
Dog
T-box 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15119-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (98)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (159)
1 – 10 of 159
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.995175142
p_ni: 1.03e-7
p_wrong: 0.004824755
Score: 0.195
Data Source: BioPlex,STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.907
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.902
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.866
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.806
Data Source: STRINGDB
RBM19
Tbio
Novelty: 0.15784228
Score: 0.8
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.791
Data Source: STRINGDB
GJA5
Tbio
Novelty: 0.00195794
Score: 0.784
Data Source: STRINGDB
SHOX2
Tbio
Family: TF
Novelty: 0.01090989
Score: 0.762
Data Source: STRINGDB
ESRRB
Tchem
Family: NR
Novelty: 0.00620739
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  218.93

PubMed score by year
PubTator Score  109.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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