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Tbio
TBX3
T-box transcription factor TBX3

Protein Summary
Description
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257566
  • ENSP00000257566
  • ENSG00000135111
  • ENST00000349155
  • ENSP00000257567

Symbol
  • UMS
  • XHL
  • TBX3-ISO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
biological process
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.9
molecular function
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.97   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.97   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (98)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Signaling pathways regulating pluripotency of stem cells
Name
Explore in Pharos
Explore in Source
Signaling pathways regulating pluripotency of stem cells
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (159)
1 – 10 of 159
HNRNPLL
Tbio
Novelty: 0.0389045
p_int: 0.995175142
p_ni: 1.03e-7
p_wrong: 0.004824755
Score: 0.195
Data Source: BioPlex,STRINGDB
BMP4
Tchem
Novelty: 0.00057391
Score: 0.907
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00046573
Score: 0.902
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.0001911
Score: 0.866
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00147966
Score: 0.806
Data Source: STRINGDB
RBM19
Tdark
Novelty: 0.30508475
Score: 0.8
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.000425
Score: 0.791
Data Source: STRINGDB
GJA5
Tbio
Novelty: 0.00254124
Score: 0.784
Data Source: STRINGDB
SHOX2
Tbio
Family: TF
Novelty: 0.01210282
Score: 0.762
Data Source: STRINGDB
ESRRB
Tchem
Family: NR
Novelty: 0.0096936
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  293.97

PubMed score by year
PubTator Score  109.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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