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Tchem
CHUK
Inhibitor of nuclear factor kappa-B kinase subunit alpha

Protein Summary
Description
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370397
  • ENSP00000359424
  • ENSG00000213341

Symbol
  • IKKA
  • TCF16
  • IKK1
  • IKKA
  • IKBKA
  • TCF16
  • NFKBIKA
  • IKK-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.99
pathway
0.99
biological term
0.98
chemical
0.98


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 550.05   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 1368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 550.05   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 1368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
29.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
conserved helix-loop-helix ubiquitous kinase
VGNC:1627
450673
Macaque
conserved helix-loop-helix ubiquitous kinase
709511
Mouse
MGI:99484
12675
Rat
RGD:1306661
309361
Dog
conserved helix-loop-helix ubiquitous kinase
VGNC:39261
477796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
conserved helix-loop-helix ubiquitous kinase
Macaque
conserved helix-loop-helix ubiquitous kinase
Mouse
Rat
Dog
conserved helix-loop-helix ubiquitous kinase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15111-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (211)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 71
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Activation of NF-kappaB in B cells
Adaptive Immune System
Antigen processing-Cross presentation
C-type lectin receptors (CLRs)
Gene Ontology Terms (53)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (261)
1 – 10 of 261
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
p_int: 0.999999943
p_ni: 2.8e-8
p_wrong: 2.9e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
p_int: 0.999999372
p_ni: 6.28e-7
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
PSG1
Tbio
Novelty: 0.0239046
p_int: 0.999997541
p_ni: 0.000002412
p_wrong: 4.7e-8
Score: 0.518
Data Source: BioPlex,STRINGDB
NFKBIA
Tchem
Novelty: 0.00022873
p_int: 0.999655555
p_ni: 0.000344442
p_wrong: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.998870774
p_ni: 0.001128521
p_wrong: 7.04e-7
Data Source: BioPlex
INSYN2
Tdark
Novelty: 2.55244594
p_int: 0.997791425
p_ni: 0.002203829
p_wrong: 0.000004746
Score: 0.305
Data Source: BioPlex,STRINGDB
IKBKB
Tchem
Family: Kinase
Novelty: 0.00090202
p_int: 0.996745796
p_ni: 0.000002203
p_wrong: 0.003252
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.993020479
p_ni: 0.006979212
p_wrong: 3.09e-7
Data Source: BioPlex
SHC4
Tbio
Novelty: 0.04623367
p_int: 0.985127993
p_ni: 0.005328847
p_wrong: 0.00954316
Score: 0.38
Data Source: BioPlex,STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  550.05

PubMed score by year
PubTator Score  379.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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