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Tbio
KIAA0391
Mitochondrial ribonuclease P catalytic subunit

Protein Summary
Description
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250377
  • ENSP00000250377
  • ENSG00000100890
  • ENST00000321130
  • ENSP00000324697
  • ENST00000534898
  • ENSP00000440915
  • ENST00000603544
  • ENSP00000473856
  • ENST00000604948
  • ENSP00000474620
  • ENST00000605870
  • ENSP00000474299

Symbol
  • MRPP3
  • MRPP3
  • PRORP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
histone modification site profile
0.89
transcription factor binding site profile
0.71
tissue sample
0.65
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999548183
p_ni:  0.000451817
Data Source:  BioPlex
THEM4
Tbio
Family:  Enzyme
Novelty:  0.0191855
p_int:  0.997988851
p_ni:  0.002011149
Score:  0.183
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.983651287
p_ni:  0.016348711
p_wrong:  1e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.975699673
p_ni:  0.024300326
Data Source:  BioPlex
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.957918894
p_ni:  0.042080953
p_wrong:  1.53e-7
Data Source:  BioPlex
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
p_int:  0.949655815
p_ni:  0.05034409
p_wrong:  9.5e-8
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.94318762
p_ni:  0.056812358
p_wrong:  2.1e-8
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.940067069
p_ni:  0.059928187
p_wrong:  0.000004744
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.938116297
p_ni:  0.06188368
p_wrong:  2.3e-8
Score:  0.328
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.926017316
p_ni:  0.07398264
p_wrong:  4.5e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA processing
rRNA processing in the mitochondrion
tRNA modification in the mitochondrion
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
85.1
monocyte percentage of leukocytes
2
2
2
83.6
neutrophil count
2
2
2
82
myeloid white cell count
1
1
1
70.2
6
2
0
1.2
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
85.1
monocyte percentage of leukocytes
2
83.6
neutrophil count
2
82
myeloid white cell count
1
70.2
0
1.2
68.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913382
66132
Rat
RGD:1305089
299050
Dog
KIAA0391 ortholog
490650
Cow
KIAA0391 ortholog
532995
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
KIAA0391 ortholog
Cow
KIAA0391 ortholog
Publication Statistics
PubMed Score 51.36
PubMed score by year
PubTator Score 23.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title