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Tbio
KIAA0391
Mitochondrial ribonuclease P catalytic subunit

Protein Summary
Description
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250377
  • ENSP00000250377
  • ENSG00000100890
  • ENST00000321130
  • ENSP00000324697
  • ENST00000534898
  • ENSP00000440915
  • ENST00000603544
  • ENSP00000473856
  • ENST00000604948
  • ENSP00000474620
  • ENST00000605870
  • ENSP00000474299

Symbol
  • MRPP3
  • MRPP3
  • PRORP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
histone modification site profile
0.89
transcription factor binding site profile
0.71
tissue sample
0.65
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0