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Tbio
ARHGEF11
Rho guanine nucleotide exchange factor 11

Protein Summary
Description
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361409
  • ENSP00000354644
  • ENSG00000132694
  • ENST00000368194
  • ENSP00000357177

Symbol
  • KIAA0380
  • GTRAP48
  • PDZ-RHOGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
hub protein
0.82
virus perturbation
0.79
biological process
0.73
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.18   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
4
9
98.4
platelet count
3
3
5
89
lymphocyte count
2
2
2
70.4
body height
1
1
1
66.8
red blood cell density measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
98.4
platelet count
5
89
lymphocyte count
2
70.4
body height
1
66.8
red blood cell density measurement
1
53.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 11
VGNC:6718
457410
Macaque
Rho guanine nucleotide exchange factor 11
718727
Mouse
MGI:2441869
213498
Rat
RGD:619705
78966
Dog
Rho guanine nucleotide exchange factor 11
VGNC:38074
490402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho guanine nucleotide exchange factor 11
Macaque
Rho guanine nucleotide exchange factor 11
Mouse
Rat
Dog
Rho guanine nucleotide exchange factor 11
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15085-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
Developmental Biology
Reactome
G alpha (12/13) signalling events
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Developmental Biology
G alpha (12/13) signalling events
Protein-Protein Interactions (95)
1 – 10 of 95
PAK5
Tchem
Family:  Kinase
Novelty:  0.02138632
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.715
Data Source:  BioPlex,STRINGDB
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
p_int:  0.999999597
p_ni:  2.79e-7
p_wrong:  1.25e-7
Score:  0.885
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.999998384
p_ni:  0.000001615
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
p_int:  0.999983044
p_ni:  0.000016955
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
p_int:  0.999932557
p_ni:  0.000067442
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.997381336
p_ni:  0.000337304
p_wrong:  0.00228136
Data Source:  BioPlex
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.978
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.978
Data Source:  STRINGDB
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.977
Data Source:  Reactome,STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.18

PubMed score by year
PubTator Score  39.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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