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Tbio
ANKRD28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Protein Summary
Description
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399451
  • ENSP00000382379
  • ENSG00000206560
  • ENST00000412318
  • ENSP00000397341
  • ENST00000624145
  • ENSP00000485421

Symbol
  • KIAA0379
  • PITK
  • PPP1R65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.91
histone modification site profile
0.89
transcription factor
0.85
microRNA
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
89.9
waist-hip ratio
1
1
1
75.8
1
1
1
65.4
body mass index
1
1
1
59.1
high density lipoprotein cholesterol measurement
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.9
waist-hip ratio
1
75.8
1
65.4
body mass index
1
59.1
high density lipoprotein cholesterol measurement
1
39.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 28
VGNC:1734
460205
Macaque
ankyrin repeat domain 28
100428048
Mouse
MGI:2145661
105522
Rat
RGD:1559931
306264
Dog
ankyrin repeat domain 28
VGNC:37893
477058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 28
Macaque
ankyrin repeat domain 28
Mouse
Rat
Dog
ankyrin repeat domain 28
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (64)
1 – 10 of 64
ANKRD44
Tdark
Family: Enzyme
Novelty: 0.38360979
p_int: 0.99999888
p_ni: 0.00000112
Score: 0.697
Data Source: BioPlex,STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.999984383
p_ni: 0.000015617
Score: 0.877
Data Source: BioPlex,STRINGDB
ZNF574
Tdark
Family: TF
Novelty: 2.72596185
p_int: 0.999786524
p_ni: 0.000213476
Score: 0.196
Data Source: BioPlex,STRINGDB
USP10
Tchem
Family: Enzyme
Novelty: 0.05830541
p_int: 0.999194837
p_ni: 0.000805163
Score: 0.563
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.998310638
p_ni: 0.001689362
Score: 0.19
Data Source: BioPlex,STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.997939704
p_ni: 0.002060296
Score: 0.322
Data Source: BioPlex,STRINGDB
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.994156797
p_ni: 0.005843203
Score: 0.202
Data Source: BioPlex,STRINGDB
PDGFRL
Tbio
Novelty: 0.0709225
p_int: 0.992401336
p_ni: 0.007598664
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.991598178
p_ni: 0.008401822
Data Source: BioPlex
UTP4
Tbio
Novelty: 0.06989008
p_int: 0.989800654
p_ni: 0.010199346
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.75

PubMed score by year
PubTator Score  41.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer