You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
DCLK1
Serine/threonine-protein kinase DCLK1

Protein Summary
Description
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255448
  • ENSP00000255448
  • ENSG00000133083
  • ENST00000360631
  • ENSP00000353846
  • ENST00000379893
  • ENSP00000369223
  • ENST00000615680
  • ENSP00000484452

Symbol
  • DCAMKL1
  • DCDC3A
  • KIAA0369
  • CL1
  • DCLK
  • CLICK1
  • DCDC3A
  • DCAMKL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
transcription factor perturbation
0.99
molecular function
0.94
trait
0.93
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.08   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.08   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0