Tchem DCLK1 Serine/threonine-protein kinase DCLK1

Protein Summary

Description

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• O15075
• B7Z3E9
• Q5VZY8
• Q5VZZ0
• Q5VZZ1

Gene Name

• DCLK1

Ensembl ID

• ENST00000255448
• ENSP00000255448
• ENSG00000133083
• ENST00000360631
• ENSP00000353846
• ENST00000379893
• ENSP00000369223
• ENST00000615680
• ENSP00000484452

Symbol

• DCAMKL1
• DCDC3A
• KIAA0369
• CL1
• DCLK
• CLICK1
• DCDC3A
• DCAMKL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	1
transcription factor perturbation	0.99
molecular function	0.94
trait	0.93
protein domain	0.92

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dcamkl Family / Serine/threonine-protein Kinase Dclk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.08   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.08   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0