Tchem DCLK1 Serine/threonine-protein kinase DCLK1

Protein Summary

Description

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• O15075
• B7Z3E9
• Q5VZY8
• Q5VZZ0
• Q5VZZ1

Gene Name

• DCLK1

Ensembl ID

• ENST00000255448
• ENSP00000255448
• ENSG00000133083
• ENST00000360631
• ENSP00000353846
• ENST00000379893
• ENSP00000369223
• ENST00000615680
• ENSP00000484452

Symbol

• DCAMKL1
• DCDC3A
• KIAA0369
• CL1
• DCLK
• CLICK1
• DCDC3A
• DCAMKL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	1
transcription factor perturbation	0.99
molecular function	0.94
trait	0.93
protein domain	0.92

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dcamkl Family / Serine/threonine-protein Kinase Dclk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.66   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.66   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (14)

Explore Active Ligands

1 – 10 of 14

TAE-684

DCLK1Tchem Kinase

pKi : 8.5

CHEMBL1673039

DCLK1Tchem Kinase

pKd : 8.92

CHEMBL4636475

DCLK1Tchem Kinase

pIC50 : 8.52

CHEMBL4643632

DCLK1Tchem Kinase

pIC50 : 8.7

XMD17-109

DCLK1Tchem Kinase

pIC50 : 7.66

CHEMBL1673048

DCLK1Tchem Kinase

pIC50 : 9

CHEMBL4634326

DCLK1Tchem Kinase

pIC50 : 8.52

CHEMBL4646447

DCLK1Tchem Kinase

pIC50 : 8.7

CHEMBL4645267

DCLK1Tchem Kinase

pIC50 : 8.4

CHEMBL4640016

DCLK1Tchem Kinase

pIC50 : 8

Protein-Protein Interactions (76)

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1 – 10 of 76

• See Interactions on String-DB

FBLIM1

Tbio

Novelty:  0.0332985

p_int:  0.99999991

p_ni:  9e-8

Data Source:  BioPlex

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.999997478

p_ni:  0.000002522

Data Source:  BioPlex

HAX1

Tbio

Novelty:  0.00749205

p_int:  0.999989994

p_ni:  0.000010004

p_wrong:  1e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

DCX

Tbio

Novelty:  0.00077614

p_int:  0.999989667

p_ni:  1e-9

p_wrong:  0.000010332

Score:  0.884

Data Source:  BioPlex,STRINGDB

DNAAF2

Tbio

Novelty:  0.01254416

p_int:  0.999974452

p_ni:  0.000024871

p_wrong:  6.77e-7

Score:  0.155

Data Source:  BioPlex,STRINGDB

DGUOK

Tbio

Family:  Kinase

Novelty:  0.00897987

p_int:  0.999900568

p_ni:  0.000082271

p_wrong:  0.000017161

Data Source:  BioPlex

CDCA8

Tbio

Novelty:  0.01448513

p_int:  0.887540283

p_ni:  0.039437233

p_wrong:  0.073022484

Score:  0.158

Data Source:  BioPlex,STRINGDB

NBEA

Tbio

Novelty:  0.02583687

Score:  0.786

Data Source:  STRINGDB

MAB21L1

Tbio

Novelty:  0.07438538

Score:  0.767

Data Source:  STRINGDB

LGR5

Tbio

Family:  GPCR

Novelty:  0.00105035

Score:  0.717

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (3)

Components (2)

Processes (13)

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GO Term	Evidence	Assigned by
protein kinase activity	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein serine/threonine kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (10)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic cup area measurement	EFO_0006940	3	3	5		85.6
mathematical ability	EFO_0004875	4	3	4		80.2
cup-to-disc ratio measurement	EFO_0006939	3	1	3		75.7
self reported educational attainment	EFO_0004784	1	1	1		61
refractive error measurement	EFO_0007814	1	1	1		45.2

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic cup area measurement	EFO_0006940	5		85.6
mathematical ability	EFO_0004875	4		80.2
cup-to-disc ratio measurement	EFO_0006939	3		75.7
self reported educational attainment	EFO_0004784	1		61
refractive error measurement	EFO_0007814	1		45.2

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Complete proteome
Developmental protein
Differentiation
Kinase
Neurogenesis
Nucleotide-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
chronotype measurement
cognitive function measurement
cup-to-disc ratio measurement
mammographic density percentage
mathematical ability
optic cup area measurement
optic disc size measurement
refractive error measurement
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	doublecortin like kinase 1	VGNC:5054	467259
Macaque	doublecortin like kinase 1		722071
Dog	doublecortin like kinase 1	VGNC:39803	477304
Horse	doublecortin like kinase 1	VGNC:17041	100062396
Opossum	doublecortin like kinase 1		100020975

Species	Name	OMA	EggNOG	Inparanoid
Chimp	doublecortin like kinase 1
Macaque	doublecortin like kinase 1
Dog	doublecortin like kinase 1
Horse	doublecortin like kinase 1
Opossum	doublecortin like kinase 1

Publication Statistics

PubMed Score 203.66

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PubTator Score 99.98

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Related Publications

Text Mined References (86)

GeneRif Annotations (55)

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PMID	Year	Title