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Tchem
DCLK1
Serine/threonine-protein kinase DCLK1

Protein Summary
Description
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system. This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255448
  • ENSP00000255448
  • ENSG00000133083
  • ENST00000360631
  • ENSP00000353846
  • ENST00000379893
  • ENSP00000369223
  • ENST00000615680
  • ENSP00000484452

Symbol
  • DCAMKL1
  • DCDC3A
  • KIAA0369
  • CL1
  • DCLK
  • CLICK1
  • DCDC3A
  • DCAMKL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
transcription factor perturbation
0.99
molecular function
0.94
trait
0.93
protein domain
0.92


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.26   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.26   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
95.9
optic cup area measurement
3
3
5
85.3
self reported educational attainment
1
1
1
84.5
cup-to-disc ratio measurement
3
1
3
69.7
cognitive function measurement
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
95.9
optic cup area measurement
5
85.3
self reported educational attainment
1
84.5
cup-to-disc ratio measurement
3
69.7
cognitive function measurement
1
69.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
doublecortin like kinase 1
VGNC:5054
467259
Macaque
doublecortin like kinase 1
722071
Dog
doublecortin like kinase 1
VGNC:39803
477304
Horse
doublecortin like kinase 1
VGNC:17041
100062396
Opossum
doublecortin like kinase 1
100020975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
doublecortin like kinase 1
Macaque
doublecortin like kinase 1
Dog
doublecortin like kinase 1
Horse
doublecortin like kinase 1
Opossum
doublecortin like kinase 1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (76)
1 – 10 of 76
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.99999991
p_ni: 9e-8
Data Source: BioPlex
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999997478
p_ni: 0.000002522
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999989994
p_ni: 0.000010004
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
DCX
Tbio
Novelty: 0.00077614
p_int: 0.999989667
p_ni: 1e-9
p_wrong: 0.000010332
Score: 0.884
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999974452
p_ni: 0.000024871
p_wrong: 6.77e-7
Score: 0.155
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999900568
p_ni: 0.000082271
p_wrong: 0.000017161
Data Source: BioPlex
CDCA8
Tbio
Novelty: 0.01448513
p_int: 0.887540283
p_ni: 0.039437233
p_wrong: 0.073022484
Score: 0.158
Data Source: BioPlex,STRINGDB
NBEA
Tbio
Novelty: 0.02583687
Score: 0.786
Data Source: STRINGDB
MAB21L1
Tbio
Novelty: 0.07438538
Score: 0.767
Data Source: STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.717
Data Source: STRINGDB
Publication Statistics
PubMed Score  193.26

PubMed score by year
PubTator Score  99.98

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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