Tbio MCF2L Guanine nucleotide exchange factor DBS

Protein Summary

Description

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• O15068
• A2A2X1
• A2A2X2
• A2A3G6
• A2A3G8
• B4DHD6
• B4DIL6
• E9PDN8
• Q5JU56
• Q5VXT1
• Q6ZWD4
• Q765G8
• Q765G9
• Q8N679

Gene Name

• MCF2L

Ensembl ID

• ENST00000375597
• ENSP00000364747
• ENSG00000126217
• ENST00000375604
• ENSP00000364754
• ENST00000375608
• ENSP00000364758
• ENST00000397030
• ENSP00000380225
• ENST00000421756
• ENSP00000397285
• ENST00000535094
• ENSP00000440374

Symbol

• KIAA0362
• OST
• DBS
• OST
• ARHGEF14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
disease perturbation	0.83
virus perturbation	0.83
transcription factor	0.66
tissue sample	0.62

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Guanine Nucleotide Exchange Factor Dbs

DTO Classes

Protein / Signaling / Guanine Nucleotide Exchange Factor Dbs

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0