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Tbio
SYNJ2
Synaptojanin-2

Protein Summary
Description
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355585
  • ENSP00000347792
  • ENSG00000078269
  • ENST00000640338
  • ENSP00000492532

Symbol
  • KIAA0348
  • INPP5H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
transcription factor binding site profile
0.91
transcription factor
0.87
co-expressed gene
0.85
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
1
0
7.1
84.4
serum gamma-glutamyl transferase measurement
1
1
1
51.2
intraocular pressure measurement
1
1
1
23.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
0
7.1
84.4
serum gamma-glutamyl transferase measurement
1
51.2
intraocular pressure measurement
1
23.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptojanin 2
VGNC:12706
463094
Mouse
MGI:1201671
20975
Rat
RGD:69436
84018
Dog
synaptojanin 2
VGNC:47033
484052
Horse
synaptojanin 2
VGNC:23808
100059716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptojanin 2
Mouse
Rat
Dog
synaptojanin 2
Horse
synaptojanin 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15056-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Metabolism
Metabolism of lipids
PI Metabolism
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (216)
1 – 10 of 216
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.999388134
p_ni: 0.000001505
p_wrong: 0.000610361
Score: 0.96
Data Source: BioPlex,STRINGDB
AMPH
Tbio
Novelty: 0.00201043
Score: 0.967
Data Source: STRINGDB
SH3GL2
Tbio
Novelty: 0.0188955
Score: 0.961
Data Source: STRINGDB
ITSN1
Tbio
Novelty: 0.01327346
Score: 0.959
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.959
Data Source: STRINGDB
SNAP91
Tbio
Novelty: 0.0083886
Score: 0.958
Data Source: STRINGDB
SH3GL3
Tbio
Novelty: 0.05467913
Score: 0.958
Data Source: STRINGDB
ITSN2
Tbio
Novelty: 0.03036854
Score: 0.955
Data Source: STRINGDB
EPS15L1
Tbio
Novelty: 0.06929299
Score: 0.955
Data Source: STRINGDB
SH3GL1
Tbio
Novelty: 0.02379336
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.13

PubMed score by year
PubTator Score  15.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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