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Tchem
PER2
Period circadian protein homolog 2

Protein Summary
Description
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254657
  • ENSP00000254657
  • ENSG00000132326

Symbol
  • KIAA0347
  • FASPS
  • FASPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
virus perturbation
0.97
molecular function
0.96
transcription factor binding site profile
0.95
PubMedID
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 636.96   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 636.96   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
5
5
1.1
93.8
mean corpuscular hemoglobin concentration
2
1
2
81.5
red blood cell distribution width
3
2
3
79.2
hemoglobin measurement
2
1
2
70.8
transferrin saturation measurement
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
5
1.1
93.8
mean corpuscular hemoglobin concentration
2
81.5
red blood cell distribution width
3
79.2
hemoglobin measurement
2
70.8
transferrin saturation measurement
1
55.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
period circadian regulator 2
VGNC:14336
460057
Macaque
period circadian regulator 2
696476
Mouse
MGI:1195265
18627
Rat
RGD:61945
63840
Dog
period circadian regulator 2
VGNC:44421
486180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
period circadian regulator 2
Macaque
period circadian regulator 2
Mouse
Rat
Dog
period circadian regulator 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15055-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene Ontology Terms (33)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (107)
1 – 10 of 107
CSNK1E
Tclin
Family:  Kinase
Novelty:  0.00891859
p_int:  0.999997194
p_ni:  9.73e-7
p_wrong:  0.000001833
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CRY2
Tbio
Novelty:  0.00156961
p_int:  0.869359829
p_ni:  0.000101546
p_wrong:  0.130538625
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CRY1
Tchem
Novelty:  0.00116593
Score:  0.999
Data Source:  Reactome,STRINGDB
BHLHE41
Tbio
Family:  TF
Novelty:  0.01015053
Score:  0.999
Data Source:  STRINGDB
CSNK1D
Tchem
Family:  Kinase
Novelty:  0.00896935
Score:  0.996
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.993
Data Source:  Reactome,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.988
Data Source:  Reactome,STRINGDB
PER1
Tbio
Novelty:  0.01290576
Score:  0.988
Data Source:  STRINGDB
NFIL3
Tbio
Family:  TF
Novelty:  0.00882074
Score:  0.986
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.983
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  636.96

PubMed score by year
PubTator Score  1619.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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