Tchem KDM6B Lysine-specific demethylase 6B

Protein Summary

Description

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• O15054
• C9IZ40
• Q96G33

Gene Name

• KDM6B

Ensembl ID

• ENST00000254846
• ENSP00000254846
• ENSG00000132510
• ENST00000448097
• ENSP00000412513

Symbol

• JMJD3
• KIAA0346
• JMJD3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.8
histone modification site profile	0.78
biological process	0.69
cell type or tissue	0.69
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Lysine-specific Demethylase 6b

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 6b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.54   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 334   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 310.54   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0