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Tbio
SETD1A
Histone-lysine N-methyltransferase SETD1A

Protein Summary
Description
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262519
  • ENSP00000262519
  • ENSG00000099381

Symbol
  • KIAA0339
  • KMT2F
  • SET1
  • SET1A
  • Set1
  • KMT2F
  • Set1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
protein domain
0.73
transcription factor binding site profile
0.72
biological process
0.68
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.93   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.93   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
54.5
mean corpuscular volume
1
1
1
53.6
neuroticism measurement
1
1
0
6.3
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
54.5
mean corpuscular volume
1
53.6
neuroticism measurement
0
6.3
22.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 1A
VGNC:5916
468101
Mouse
MGI:2446244
233904
Dog
SET domain containing 1A
VGNC:46052
489916
Horse
SET domain containing 1A
VGNC:51238
100063523
Cow
SET domain containing 1A
VGNC:34492
782887
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 1A
Mouse
Dog
SET domain containing 1A
Horse
SET domain containing 1A
Cow
SET domain containing 1A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O15047-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
PKMTs methylate histone lysines
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (326)
1 – 10 of 326
CXXC1
Tbio
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.999999875
p_ni: 1.25e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.99999921
p_ni: 7.9e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.999998326
p_ni: 0.000001674
Score: 0.59
Data Source: BioPlex,STRINGDB
EPB41L5
Tbio
Novelty: 0.0391959
p_int: 0.99999381
p_ni: 0.00000619
Score: 0.612
Data Source: BioPlex,STRINGDB
MDK
Tchem
Novelty: 0.00145301
p_int: 0.999983477
p_ni: 0.000016523
Score: 0.546
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.999961303
p_ni: 0.000038697
Data Source: BioPlex
NUP50
Tbio
Novelty: 0.03424725
p_int: 0.999408092
p_ni: 0.000591907
Score: 0.16
Data Source: BioPlex,STRINGDB
PES1
Tbio
Novelty: 0.07162845
p_int: 0.999017611
p_ni: 0.000982389
Score: 0.253
Data Source: BioPlex,STRINGDB
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.998999588
p_ni: 0.001000412
Data Source: BioPlex
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.998924745
p_ni: 0.001075255
Data Source: BioPlex
Publication Statistics
PubMed Score  383.93

PubMed score by year
PubTator Score  310.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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