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Tbio
SEMA3E
Semaphorin-3E

Protein Summary
Description
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307792
  • ENSP00000303212
  • ENSG00000170381
  • ENST00000427262
  • ENSP00000405052
  • ENST00000643230
  • ENSP00000496491

Symbol
  • KIAA0331
  • SEMAH
  • SEMAH
  • coll-5
  • M-SEMAH
  • M-SemaK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.96
transcription factor perturbation
0.8
PubMedID
0.69
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.32   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
68.1
wellbeing measurement
3
2
3
36.5
unipolar depression
1
1
0
1
9.2
neuroticism measurement
1
1
1
4.8
depressive symptom measurement
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
68.1
wellbeing measurement
3
36.5
unipolar depression
0
1
9.2
neuroticism measurement
1
4.8
depressive symptom measurement
1
4.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3E
VGNC:8751
472429
Macaque
semaphorin 3E
707673
Mouse
MGI:1340034
20349
Rat
RGD:1310973
296789
Dog
semaphorin 3E
VGNC:45991
483387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3E
Macaque
semaphorin 3E
Mouse
Rat
Dog
semaphorin 3E
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15041-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Gene Ontology Terms (18)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (87)
1 – 10 of 87
GLDC
Tbio
Family:  Enzyme
Novelty:  0.00900467
p_int:  0.999117492
p_ni:  0.000882508
Data Source:  BioPlex
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.995
Data Source:  Reactome,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.985
Data Source:  STRINGDB
PLXNA4
Tbio
Novelty:  0.01807048
Score:  0.965
Data Source:  STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.964
Data Source:  STRINGDB
PLXNA3
Tbio
Novelty:  0.02016528
Score:  0.964
Data Source:  STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
Score:  0.957
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.947
Data Source:  STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
Score:  0.937
Data Source:  STRINGDB
RND2
Tbio
Family:  Enzyme
Novelty:  0.01278315
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  112.32

PubMed score by year
PubTator Score  31.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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