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Tdark
RIMBP2
RIMS-binding protein 2

Protein Summary
Description
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261655
  • ENSP00000261655
  • ENSG00000060709

Symbol
  • KIAA0318
  • RBP2
  • RBP2
  • RIM-BP2
  • PPP1R133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.84
gene perturbation
0.62
protein domain
0.58
tissue
0.56
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
RIMS2
Tbio
Novelty:  0.02785894
Score:  0.925
Data Source:  STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.848
Data Source:  STRINGDB
RAB3C
Tbio
Family:  Enzyme
Novelty:  0.06291754
Score:  0.837
Data Source:  STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
Score:  0.795
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.775
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.766
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.747
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.745
Data Source:  STRINGDB
CACNA1D
Tclin
Family:  IC
Novelty:  0.00314752
Score:  0.733
Data Source:  STRINGDB
UNC13A
Tbio
Novelty:  0.01009835
Score:  0.732
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
1
1
2
72.1
testosterone measurement
3
1
3
70
tissue plasminogen activator measurement
2
2
2
49.2
longevity
1
1
0
5.8
24.5
age at menopause
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
72.1
testosterone measurement
3
70
tissue plasminogen activator measurement
2
49.2
longevity
0
5.8
24.5
age at menopause
1
8.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RIMS binding protein 2
718140
Mouse
MGI:2443235
231760
Rat
RGD:708533
266780
Dog
RIMS binding protein 2
VGNC:45579
100856418
Horse
RIMS binding protein 2
VGNC:50965
100060373
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RIMS binding protein 2
Mouse
Rat
Dog
RIMS binding protein 2
Horse
RIMS binding protein 2
Publication Statistics
PubMed Score 16.07
PubMed score by year
PubTator Score 1.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title