Tbio AREL1 Apoptosis-resistant E3 ubiquitin protein ligase 1

Protein Summary

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.

Uniprot Accession IDs

• O15033
• B4E2C7
• Q7LDY1
• Q8IYY9

Gene Name

• AREL1

Ensembl ID

• ENST00000356357
• ENSP00000348714
• ENSG00000119682

Symbol

• KIAA0317
• FIEL1
• KIAA0317

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
protein domain	0.73
microRNA	0.6
cell line	0.59
tissue sample	0.57

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Apoptosis-resistant E3 Ubiquitin Protein Ligase 1

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Apoptosis-resistant E3 Ubiquitin Protein Ligase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0