Tbio PLXNB2 Plexin-B2

Protein Summary

Description

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O15031
• A6QRH0
• Q7KZU3
• Q9BSU7

Gene Name

• PLXNB2

Ensembl ID

• ENST00000359337
• ENSP00000352288
• ENSG00000196576
• ENST00000449103
• ENSP00000409171

Symbol

• KIAA0315
• MM1
• PLEXB2
• Nbla00445
• dJ402G11.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.96
transcription factor perturbation	0.91
cell line	0.69
phenotype	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.35   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.35   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0