Protein Summary
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
- ENST00000359337
- ENSP00000352288
- ENSG00000196576
- ENST00000449103
- ENSP00000409171
- KIAA0315
- MM1
- PLEXB2
- Nbla00445
- dJ402G11.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.91 | ||
cell line | 0.69 | ||
phenotype | 0.69 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.77 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.77 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 4 | 97.7 | |||||
platelet crit | 2 | 3 | 4 | 97.7 | |||||
mitochondrial DNA measurement | 1 | 2 | 2 | 76.1 | |||||
eosinophil count | 2 | 1 | 2 | 68.3 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 63.7 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 4 | 97.7 | |||||
platelet crit | 4 | 97.7 | |||||
mitochondrial DNA measurement | 2 | 76.1 | |||||
eosinophil count | 2 | 68.3 | |||||
low density lipoprotein cholesterol measurement | 1 | 63.7 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | plexin B2 | 720646 | ||||||
Mouse | MGI:2154239 | 140570 | ||||||
Rat | RGD:1305495 | 315217 | ||||||
Dog | plexin B2 | VGNC:44723 | 474459 | |||||
Horse | plexin B2 | VGNC:21604 | 100056317 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (1)
KEGG (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Gene Ontology Terms (19)
Functions (1)
Components (4)
Processes (14)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (95)
1 – 10 of 95
TMX1
Novelty: 0.03444237
p_int: 0.999974804
p_ni: 0.000025196
Score: 0.512
Data Source: BioPlex,STRINGDB
RHOD
Family: Enzyme
Novelty: 0.0029764
p_int: 0.999682679
p_ni: 0.000317321
Score: 0.478
Data Source: BioPlex,STRINGDB
LYPD6
Novelty: 0.13867181
p_int: 0.998571188
p_ni: 0.001428812
Score: 0.189
Data Source: BioPlex,STRINGDB
DEFA1
Novelty: 0.01027492
p_int: 0.997618859
p_ni: 0.002381139
p_wrong: 1e-9
Data Source: BioPlex
SEMA4C
Novelty: 0.01237067
p_int: 0.994935979
p_ni: 0.005064021
Score: 0.804
Data Source: BioPlex,STRINGDB
SCGB2A1
Novelty: 0.01902973
p_int: 0.994839149
p_ni: 0.005160851
Data Source: BioPlex
DEFA5
Novelty: 0.00863727
p_int: 0.985219227
p_ni: 0.014780773
Data Source: BioPlex
RLN1
Novelty: 0.03992636
p_int: 0.979464943
p_ni: 0.020535057
Data Source: BioPlex
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.978179006
p_ni: 0.021820993
Data Source: BioPlex
CD160
Novelty: 0.01511748
p_int: 0.965407322
p_ni: 0.034592678
Data Source: BioPlex
Publication Statistics
PubMed Score 50.77
PubMed score by year
PubTator Score 55.23
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|