Protein Summary
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
- ENST00000359337
- ENSP00000352288
- ENSG00000196576
- ENST00000449103
- ENSP00000409171
- KIAA0315
- MM1
- PLEXB2
- Nbla00445
- dJ402G11.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.91 | ||
cell line | 0.69 | ||
phenotype | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.77 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.77 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (95)
TMX1
Novelty: 0.03444237
p_int: 0.999974804
p_ni: 0.000025196
Score: 0.512
Data Source: BioPlex,STRINGDB
RHOD
Family: Enzyme
Novelty: 0.0029764
p_int: 0.999682679
p_ni: 0.000317321
Score: 0.478
Data Source: BioPlex,STRINGDB
LYPD6
Novelty: 0.13867181
p_int: 0.998571188
p_ni: 0.001428812
Score: 0.189
Data Source: BioPlex,STRINGDB
DEFA1
Novelty: 0.01027492
p_int: 0.997618859
p_ni: 0.002381139
p_wrong: 1e-9
Data Source: BioPlex
SEMA4C
Novelty: 0.01237067
p_int: 0.994935979
p_ni: 0.005064021
Score: 0.804
Data Source: BioPlex,STRINGDB
ST8SIA4
Family: Enzyme
Novelty: 0.00338436
p_int: 0.978179006
p_ni: 0.021820993
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (1)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 4 | 97.7 | |||||
platelet crit | 2 | 3 | 4 | 97.7 | |||||
mitochondrial DNA measurement | 1 | 2 | 2 | 76.1 | |||||
eosinophil count | 2 | 1 | 2 | 68.3 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 63.7 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 4 | 97.7 | |||||
platelet crit | 4 | 97.7 | |||||
mitochondrial DNA measurement | 2 | 76.1 | |||||
eosinophil count | 2 | 68.3 | |||||
low density lipoprotein cholesterol measurement | 1 | 63.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | plexin B2 | 720646 | ||||||
Mouse | MGI:2154239 | 140570 | ||||||
Rat | RGD:1305495 | 315217 | ||||||
Dog | plexin B2 | VGNC:44723 | 474459 | |||||
Horse | plexin B2 | VGNC:21604 | 100056317 | |||||
Publication Statistics
PubMed Score 50.77
PubMed score by year
PubTator Score 55.23
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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