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Tbio
SEC16A
Protein transport protein Sec16A

Protein Summary
Description
Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By simila ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313050
  • ENSP00000325827
  • ENSG00000148396

Symbol
  • KIAA0310
  • SEC16
  • SEC16L
  • p250
  • SEC16L
  • KIAA0310
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
0.96
ligand (protein) perturbation
0.96
interacting protein
0.93
histone modification site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.5   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.5   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.994898315
p_ni:  0.005101685
Score:  0.845
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.927475243
p_ni:  0.072524757
Data Source:  BioPlex
REC8
Tbio
Novelty:  0.00732742
p_int:  0.890175634
p_ni:  0.109824366
Data Source:  BioPlex
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.871383314
p_ni:  0.128616686
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NEFL
Tbio
Novelty:  0.00049255
p_int:  0.792011824
p_ni:  0.207988176
Score:  0.309
Data Source:  BioPlex,STRINGDB
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.997
Data Source:  Reactome,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.996
Data Source:  Reactome,STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.995
Data Source:  Reactome,STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.993
Data Source:  Reactome,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.992
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
10
4
1.1
98.8
3
4
1
1.2
96.3
HbA1c measurement
3
3
3
94.5
2
2
0
1.2
93.4
4
4
1
1.1
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.8
1
1.2
96.3
HbA1c measurement
3
94.5
0
1.2
93.4
1
1.1
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC16 homolog A, endoplasmic reticulum export factor
721736
Mouse
MGI:2139207
227648
Rat
RGD:2322350
100360302
Dog
SEC16 homolog A, endoplasmic reticulum export factor
VGNC:45965
607434
Horse
SEC16 homolog A, endoplasmic reticulum export factor
VGNC:22786
100068746
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC16 homolog A, endoplasmic reticulum export factor
Mouse
Rat
Dog
SEC16 homolog A, endoplasmic reticulum export factor
Horse
SEC16 homolog A, endoplasmic reticulum export factor
Publication Statistics
PubMed Score 53.50
PubMed score by year
PubTator Score 12.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title