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Tbio
TRIM66
Tripartite motif-containing protein 66

Protein Summary
Description
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299550
  • ENSP00000299550
  • ENSG00000166436

Symbol
  • C11orf29
  • KIAA0298
  • TIF1D
  • C11orf29
  • TIF1DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.85
microRNA
0.78
gene perturbation
0.76
disease perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
11
6
17
94.7
waist-hip ratio
3
2
3
82
2
2
2
80.6
age at menarche
2
2
1
2.3
65.7
hemoglobin measurement
1
1
1
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
94.7
waist-hip ratio
3
82
2
80.6
age at menarche
1
2.3
65.7
hemoglobin measurement
1
59.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 66
709067
Mouse
MGI:2152406
330627
Rat
RGD:1595847
361623
Dog
tripartite motif containing 66
VGNC:47833
485379
Horse
tripartite motif containing 66
VGNC:24521
100070991
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 66
Mouse
Rat
Dog
tripartite motif containing 66
Horse
tripartite motif containing 66
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O15016-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
TRIM46
Tbio
Novelty:  0.04333865
Score:  0.7
Data Source:  STRINGDB
TRIM17
Tbio
Family:  Enzyme
Novelty:  0.00984948
Score:  0.64
Data Source:  STRINGDB
CBX3
Tbio
Family:  Epigenetic
Novelty:  0.00776486
Score:  0.63
Data Source:  STRINGDB
CBX1
Tbio
Family:  Epigenetic
Novelty:  0.00343221
Score:  0.624
Data Source:  STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
Score:  0.6
Data Source:  STRINGDB
TRIM54
Tbio
Novelty:  0.0198735
Score:  0.587
Data Source:  STRINGDB
RNF207
Tbio
Novelty:  0.27385519
Score:  0.579
Data Source:  STRINGDB
TRIM3
Tbio
Novelty:  0.0188159
Score:  0.57
Data Source:  STRINGDB
TRIM67
Tdark
Novelty:  0.02511888
Score:  0.559
Data Source:  STRINGDB
GALNTL5
Tbio
Family:  Enzyme
Novelty:  0.17882969
Score:  0.551
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.33

PubMed score by year
PubTator Score  2.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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