Tbio ZNF609 Zinc finger protein 609

Protein Summary

Description

Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.

Uniprot Accession IDs

• O15014
• Q0D2I2

Gene Name

• ZNF609

Ensembl ID

• ENST00000326648
• ENSP00000316527
• ENSG00000180357

Symbol

• KIAA0295

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
virus perturbation	0.79
small molecule perturbation	0.77
microRNA	0.75
cell line	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 37   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.3   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0