ARHGEF10
Rho guanine nucleotide exchange factor 10
Protein Summary
May play a role in developmental myelination of peripheral nerves. This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000349830
- ENSP00000340297
- ENSG00000104728
- ENST00000398564
- ENSP00000381571
- ENST00000518288
- ENSP00000431012
- ENST00000520359
- ENSP00000427909
- ENST00000610399
- ENSP00000481974
- ENSG00000274726
- ENST00000619613
- ENSP00000477988
- ENST00000631758
- ENSP00000488343
- ENST00000633616
- ENSP00000488463
- KIAA0294
- SNCV
- GEF10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.62 | ||
tissue sample | 0.62 | ||
cell line | 0.61 | ||
tissue | 0.58 | ||
disease | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.51 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.51 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0