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Tbio
SYN3
Synapsin-3

Protein Summary
Description
May be involved in the regulation of neurotransmitter release and synaptogenesis. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358763
  • ENSP00000351614
  • ENSG00000185666
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.97
cellular component
0.8
molecular function
0.76
disease
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.48   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.48   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.4
98.3
body height
3
3
3
93.3
intraocular pressure measurement
4
3
5
86.1
atrophic macular degeneration
1
1
0
1.3
83.6
1
1
0
1.3
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
98.3
body height
3
93.3
intraocular pressure measurement
5
86.1
atrophic macular degeneration
0
1.3
83.6
0
1.3
83.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
synapsin III
100430213
Mouse
MGI:1351334
27204
Rat
RGD:3799
29130
Dog
synapsin III
481290
Horse
synapsin III [Source:HGNC Symbol;Acc:HGNC:11496]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
synapsin III
Mouse
Rat
Dog
synapsin III
Horse
synapsin III [Source:HGNC Symbol;Acc:HGNC:11496]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O14994-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Dopamine Neurotransmitter Release Cycle (R-HSA-212676)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Serotonin Neurotransmitter Release Cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Dopamine Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Serotonin Neurotransmitter Release Cycle
Transmission across Chemical Synapses
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Protein-Protein Interactions (81)
1 – 10 of 81
SYT1
Tbio
Novelty: 0.00176103
Score: 0.973
Data Source: STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.971
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
Score: 0.96
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00187736
Score: 0.951
Data Source: STRINGDB
STX1A
Tbio
Novelty: 0.00087207
Score: 0.946
Data Source: STRINGDB
RIMS1
Tbio
Novelty: 0.01126545
Score: 0.941
Data Source: STRINGDB
CPLX1
Tbio
Novelty: 0.01434543
Score: 0.936
Data Source: STRINGDB
UNC13B
Tbio
Novelty: 0.00429808
Score: 0.935
Data Source: STRINGDB
SYN1
Tbio
Novelty: 0.00093242
Score: 0.932
Data Source: STRINGDB
SYN2
Tbio
Novelty: 0.00574709
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  147.48

PubMed score by year
PubTator Score  60.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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